The growth and development of follicles within the ovary are highly dependent on autocrine and paracrine signaling involving growth factors from granulosa cells, theca cells, stromal interstitial cells, and the oocytes. The growth factor bone morphogenetic protein-4 (BMP-4) and its receptor (BMPR-IB) have been detected in ovaries, and a mutation in BMPR-IB has been associated with abnormal ovul...

abstract background: “polycystic ovary syndrome (pcos) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction”. “autonomic and central nervous systems play important roles in the regulation of ovarian physiology”. the noradrenergic nucleus locus coeruleus (lc) plays a central role in the regulation of the sympathetic nervous system and synaptically connected to the ...

OBJECTIVE To describe and evaluate the assays used to measure the antibody responses in infants to 13 experimental acellular pertussis vaccines and 2 licensed whole-cell pertussis vaccines. METHODS During a 53-week period, preimmunization and postimmunization sera were assayed for immunoglobulin G antibodies to pertussis toxin, filamentous hemagglutinin, pertactin, and a mixture of type 2 and...

ObjectiveTo report the utility of combined transvaginal and transabdominal oocyte retrieval in a patient with an ectopic ovary unicornuate uterus.DesignVideo case demonstration technique.Setting(s)University-affiliated fertility center.Patient(s)A 35-year-old woman, gravida 0, 6-month history infertility who presented to our center for evaluation. Hysterosalpingography revealed left uterus pate...

A sterol-requiring mutant has been isolated from mutagenized Chinese hamster ovary cells. This mutant grows normally only when cholesterol is present in the medium. Cell lysis occurs within 3 days in the absence of cholesterol. The frequency of reversion of this mutant to prototrophic growth is low (less than or equal to 10(-6). Whole cell pulse experiments with [14C]acetate or [3H]mevalonate i...

OBJECTIVE To evaluate recovery of endocrine function and fertility after transplantation and vitrification of whole ovaries. DESIGN Animal study. SETTING Lyon Veterinary School, France. ANIMAL(S) Ewes. INTERVENTION(S) In group 1 (n = 5), the left ovary was removed with its vascular pedicle and was transplanted onto the contralateral pedicle. In group 2 (n = 5), the left ovary with its p...

BACKGROUND Transplantation of ovarian tissue is, at present, the only clinical option available to restore fertility using cryopreserved ovarian tissue. More than 30 transplantations of cryopreserved tissue have been reported, and six babies have been born, worldwide, following this procedure. Despite these encouraging results, it is essential to optimize the procedure by improving the follicul...

STUDY QUESTION Does directional freezing improve the structural and functional integrity of ovarian fragments compared with conventional slow freezing and to whole ovary cryopreservation? SUMMARY ANSWER Compared with slow freezing, the use of directional freezing significantly improves all structural and functional parameters of ovarian fragments assessed in vitro and, overall, whole ovaries ...