A synthesis of ±-cherylline dimethyl ether is reported. The key steps involved are Michael-type addition, radical azidonation of an aldehyde, Curtius rearrangement, and reduction of an isocyanate intermediate followed by Pictet-Spengler cyclization.

Convenient methods for the preparation of 1-alkoxydienes are reviewed. It is shown that 1-alkoxydienes are very reactive and can be successfully used for the synthesis of polyene compounds. These include some important natural products, such as polyene aldehydes, vitamin A aldehyde, the ethers and esters of vitamin A, f3-ionolidenacetaldehyde, f3-C,9-aldehyde and other related compounds. A conv...

[Chemical reaction: See text] The synthesis and unique reactivity of a series of arylsulfonate-based nucleophile assisting leaving groups (NALG) containing oligomeric ether units (including crown ethers) attached to the arylsulfonyl ring in the ortho orientation are described. The reactions of a variety of these ether-containing alkyl sulfonates with metal halides proceeded at substantially gre...

Despite the availability of a large number of alkyl tetrahydrofurfuryl ethers that have a wide range of applications, pure bis(tetrahydrofurfuryl) ether (BTHFE) has not been previously synthesized. Here, we report the synthesis of BTHFE (consisting of the RR, SS, and meso stereoisomers) at greater than 99 % purity from tetrahydrofurfuryl alcohol, using (tetrahydrofuran-2-yl)methyl methanesulfon...

This chapter will focus on the first two questions. The last question is equally important — of course we need to know the best way to make predictions, perform diagnoses and make strategic decisions — but in the absence of a well-entrenched mathematical calculus of causality, the answers given to the last question tend to depend on the answers provided to the first two questions. Standard resp...