The aim of this study was to examine whether control of vascular resistance by vagal afferents is altered in the early as well as late stage of hypertension. We examined the effects of vagotomy on hindlimb vascular resistance as well as on arterial baroreflex control of hindlimb vascular resistance in spontaneously hypertensive rats and Wistar-Kyoto rats, 12 and 35 weeks old. Vagotomy in rats w...

We report on five 6-month experiments during which five colonies of four male and four female rats were exposed to psychosocial stress. Monthly blood pressure measurements by a tail-cuff method showed a modest (10 mm Hg) increase in two studies using Sprague-Dawley rats. In two further studies using the more aggressive Long-Evans strain, terminal direct carotid arterial pressures were taken as ...

The effects of severe protein malnutrition (4%) on myenteric neurons of Wistar rat duodenum, in relation to a standard 22%-protein diet for rodents, were assessed in this study. Segments of the duodenum from 10 rats from each nutritional group were submitted to the elaboration of whole mounts - 5 stained with Giemsa to determine the total population of myenteric neurons and the others stained b...

BACKGROUND Glucocorticoid (GC)-induced osteonecrosis (ON) is an important complication of medical therapy. The exact pathomechanisms of ON has not been clearly elucidated. There is a need for a reproducible animal model that better approximates the clinical scenario. METHODS To determine the genetic susceptibility of rats to develop GC-induced femoral head ON, we evaluated 5 different inbred ...

Radioprotective effects of ethanolic extracts Gongronema latifolium leaf against radiation induced oxidative stress in Wistar albino Rats

The way hippocampal neurons function during stress in old age (critical times of life) is dependent on brain derived neurotrophin factor (BDNF). This study examined the influence of acute and chronic forced swim (FS) or high-light open field (HL‑OF) stimulation on the density of BDNF immunoreactive (ir) neurons in the hippocampal pyramidal layers of CA1, CA2, CA3 regions and the granular layer ...

Grace V. O’Donovan, Houdini H.T. Wu, Oona Y-C. Lee, Ramasamyiyer Swaminathan, Graham F. Cope and Heather J. Milburn Dept of Respiratory Medicine, Mayday University Hospital, Croydon, Dept of Biochemistry, Guy’s and St Thomas’ NHS Foundation Trust, London, King’s College London School of Medicine, University of London, London, Dept of Respiratory Medicine, Guy’s and St Thomas’ NHS Foundation Tru...

Article history: Received on: 08/11/2012 Revised on: 29/11/2012 Accepted on: 15/12/2012 Available online: 28/01/2013 In this study, assessment of the potential effect of cypermethrin-treated lettuce on the rat liver physiology is carried out. Cypermethrin-treated lettuce and three doses of cypermethrin (CY) were administered during 28 days to rats. Along the experimental period, animal behavior...