NOTICE This technical report does not necessarily represent final EPA decisions or positions. It is intended to present technical analysis of issues using data which are currently available. The purpose in the release of such reports is to facilitate the exchange of technical information and to inform the public of technical developments which may form the basis for a final EPA decision, positi...

Wolcott-Rallison syndrome (WRS) is an autosomal recessive disease, characterized by neonatal or early-onset non-autoimmune insulin-dependent diabetes. WRS, although rare, is recognized to be the most frequent cause of neonatal-onset diabetes. The majority of reported patients are from consanguineous families. Several mutations with variable expression of the syndrome are reported. Here we descr...

The New World species of the genus Cremnops are revised. Thirty-three species of Cremnops are treated; five are described as new, i.e., C. bertae sp. nov., C. cluttsis sp. nov., C. nymphius sp. nov., C. wileycoyotius sp. nov. and C. witkopegasus sp. nov. Six species are synonymized, i.e., Cremnops caribensis Berta, 1998, is synonymized under C. guanicanus Wolcott, 1924; C. nigrosternum (Morriso...

This study presents a detailed taxonomic review of water mites of the genus Unionicola Haldeman, 1842 (Hygrobatoidea: Unionicolidae) found in the fauna of Russia during the long-term survey period of 1969-2013. The review includes (re)descriptions and illustrations of 21 Unionicola species found in this country: Unionicola intermedia (Koenike, 1882), U. crassipes (O.F. Müller, 1776), U. rossica...

2. Expert Group on Safe Medication Practices. Creation of a better medication safety culture in Europe: building up safe medication practices. Strasbourg: Council of Europe; 2006. 3. Aspden P, Wolcott JA, Lyle Bootman J, Cronenwett LR, editors. Preventing medication errors. Committee on Identifying and Preventing Medication Errors, Institute of Medicine. Washington, DC: National Academy Press; ...

Plastic reflective mulches significantly reduced populations of corn leafhopper, Dalbulus maidis (DeLong & Wolcott), adults and the incidence of corn stunt disease caused by Spiroplasma kunkelii (CSS) in late planted sweet corn (Zea mays L.). The reflective mulches were more effective than were either foliar or soil applied insecticides in managing both the leafhopper and the pathogen it transm...

When the Oncology Nursing Society (ONS) was almost exactly half its present age, in November 1994, a Boston Globe health columnist named Betsy Lehman was admitted to the Dana-Farber Cancer Institute in Boston, Massachusetts, to receive an investigational regimen for breast cancer. Her treatment ended in disaster. In one of the most notorious patient safety failures of modern times, Lehman was g...

W olcott-Rallison syndrome (OMIM 226980) is a rare autosomal recessive disorder characterised by permanent insulin requiring diabetes developing in the newborn period or early infancy, an early tendency to skeletal fractures, and spondyloepiphyseal dysplasia. The syndrome results from mutations in the gene encoding the eukaryotic translation initiation factor 2-a kinase 3 (EIF2AK3, also called ...

Dysregulated endoplasmic reticulum stress and phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) are associated with pancreatic β-cell failure and diabetes. Here, we report the first homozygous mutation in the PPP1R15B gene (also known as constitutive repressor of eIF2α phosphorylation [CReP]) encoding the regulatory subunit of an eIF2α-specific phosphatase in two siblings a...

Adoption of the Internet by a critical mass of the world population (1.25 billion users as of 2007, according to Internet World Stats, 2007) has changed the nature and scope of commercial transactions. Increasingly more people worldwide engage in “buying, selling, transferring, or exchanging products, services, and/or information via computer networks, including Internet” (Turban, King, Viehlan...