PURPOSE To determine if there is a heterogeneous pattern of endothelin (ET) receptor subtype (i.e., ETA and ETB) gene expression in the bovine corneal epithelium (BCE). To determine if ET receptor subtype stimulation increases the effectiveness of epidermal growth factor (EGF) to accelerate wound closure in a primary culture of bovine corneal epithelial cells (BCEC). METHODS In situ hybridiza...

BACKGROUND Numerous proangiogenic growth factors have been shown to improve impaired wound healing. This study evaluated the effects of subcutaneous pretreatment with a combination of proangiogenic growth factors on wound closure, mechanical properties, vessel density, and morphology. METHODS Thirty-six Balb/c mice with streptozotocin-induced diabetes were divided into 3 groups. A mixture of ...

Impaired wound healing can lead to scarring, and aesthetical and functional problems. The cytoprotective haem oxygenase (HO) enzymes degrade haem into iron, biliverdin and carbon monoxide. HO-1 deficient mice suffer from chronic inflammatory stress and delayed cutaneous wound healing, while corneal wound healing in HO-2 deficient mice is impaired with exorbitant inflammation and absence of HO-1...

The complete healing of wounds is the final step in a highly regulated response to injury. Although many of the molecular mediators and cellular events of healing are known, their manipulation for the enhancement and acceleration of wound closure has not proven practical as yet. We and others have established that adenosine is a potent regulator of the inflammatory response, which is a componen...

OBJECTIVE Method of skin-subcutaneous closure after inguinal herniorrhaphy affects the operation time and immediate outcome of the wound. The study was aimed to assess the effects of a single layer closure of the skin and subcutaneous wound of inguinal herniorrhaphy, in contrast to the conventional two layer closure. METHOD DESIGN Prospective randomized controlled trials. SETTING Obafemi...

Wound complications such as infection, hematoma and seroma formation are major causes of delayed recovery and prolonged hospital stay after cesarean delivery. In addition to surgical technique, suture materials are implicated in these complications. Subcutaneous fat tissue is particularly susceptible to developing such problems because of its poor vascular supply. To investigate any difference ...

PURPOSE Infection is one of the most frequent complications that can occur after ileostomy closure. The incidence of wound infection depends on the skin closure technique, but there is no agreement on the perfect closure method for an ileostomy wound. The aim of this study was to evaluate the incidence of infection, the patient's approval, and the patient's pain between purse-string closure (PS...

BACKGROUND Cathepsin S is a cysteine protease, which is expressed in human periodontal ligament (PDL) cells under inflammatory and infectious conditions. This in vitro study was established to investigate the effect of cathepsin S on PDL cell wound closure. METHODS An in vitro wound healing assay was used to monitor wound closure in wounded PDL cell monolayers for 72 h in the presence and abs...

BACKGROUND The influence of patient preference and treatment costs has not been considered in previous analyses of wound management decisions for contaminated right lower quadrant incisions. STUDY DESIGN We performed a decision and cost-utility analysis, conducting a MEDLINE search of the postappendectomy wound infection literature to establish assumptions and assign baseline probability esti...

This study evaluated the wound healing potential of Spathodea campanulata stem bark in Sprague Dawley rats using the excision wound model. The methanol extract contained glycosides, flavonoids and tannins, and was relatively stable when stored at the room temperature for six (6) months. Solvent-free, semi-solid extract of S. campanulata was incorporated into an aqueous cream and applied (10 % w...