o,p'-DDT is an infamous xenoestrogen as well as a ubiquitous and persistent pollutant. Biomonitoring studies show that women have been internally exposed to o,p'-DDT at range of 0.3-500 ng/g (8.46×10(-10) M-1.41×10(-6) M) in blood and other tissues. However, very limited studies have investigated the biological effects and mechanism(s) of o,p'-DDT at levels equal to or lower than current exposu...

Hormone-activated ERs (ERalpha and ERbeta) bind with high affinity to specific DNA sequences, estrogen response elements (EREs), located within the regulatory regions of target genes. Once considered to function solely as receptor tethers, there is an increasing amount of recent evidence to suggest that the sequence of the ERE can influence receptor activity. In this study, we have performed a ...

OBJECTIVES Bishphenol A (BPA) is a representative endocrine disruptor and is also known as a xenoestrogen. The objective of the present study is to investigate how many patients are exposed to BPA and to analyze the relationships between serum BPA concentration, bone mineral density (BMD) and biochemical bone markers in postmenopausal women with osteoporosis. METHODS Total 51 patients were en...

Abstract Background In the present study, we aimed to investigate selected functions of human neutrophils exposed bisphenol A (BPA) under in vitro conditions. As BPA is classified among xenoestrogens, compared its action and effects with those 17β-estradiol (E2). Methods Chemotaxis was examined using Boyden chamber. Their phagocytosis nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)...

Introduction Natural and synthetic estrogens are pollutants found in aquatic ecosystems at low concentrations reaching ng.L -1 to μg.L . At these concentrations, they able interfere with the fish endocrine system. When waterborne exposure occurs early life stages, when blood low, this may have significant consequences for estrogen-sensitive functions such as skeletal development. Methods To bet...

The growing awareness worldwide ove r the deleterious effects of endocrine disruptors on human health has created a need for screening systems to detect xenoestrogens, a diverse group of chemicals that mimic estrogenic actions and are assumed to decrease mail fertility and induce hormone related cancers in females. Here we describe a novel, classselective detector that uses fast impedance measu...

BACKGROUND Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity i...

There are controversies about adverse effects of bisphenol A (BPA), a ubiquitous xenoestrogen, on reproduction and development of male animals. To understand BPA action and assess its risk more completely, we examined the impact of BPA at high doses on the testes of pubertal male Kunming (China) mice. BPA at 0 (control), 160, 480, and 960 mg/kg/day was given by gavage to mice from postnatal day...

Bisphenol-A (BPA) is an industrial xenoestrogen used widely in our living environment. Recently, several studies suggested that BPA has destructive effects on DNA and chromosomes in normal body cells via estrogen receptors (ER). Therefore, BPA could be considered as an important mediator in many diseases such as cancer. However, there are still many controversial issues which need clarification...