Extreme Programming (XP) is becoming popular as a software development method and there is quite a lot of literature describing its philosophy and practices. However, in all of this literature Software Configuration Management (SCM) is almost never mentioned explicitly, leaving XP practitioners with the impression that SCM is not needed and SCM people with the impression that XP is not sound fr...

Children with the recessive genetic disorder Xeroderma Pigmentosum (XP) have extreme sensitivity to UV-light, a 10,000-fold increase in skin cancers from age 2 and rarely live beyond 30 years. There are seven genetic subgroups of XP, which are all resultant of pathogenic mutations in genes in the nucleotide excision repair (NER) pathway and a XP variant resultant of a mutation in translesion sy...

Laurie Williams, Department of Computer Science, North Carolina State University, Raleigh, NC 27695, [email protected] 2 Richard Upchurch, Computer and Information Science Department, University of Massachusetts Dartmouth, N. Dartmouth, MA 02747, [email protected] Abstract  The eXtreme Programming (XP) software development methodology has received considerable attention in recent years....

XP-F cDNA was cloned into a mammalian expression vector plasmid, and introduced into group F xeroderma pigmentosum (XP-F) cells. Several cell clones possessing transfected XPF cDNA were randomly isolated, and DNA repair characteristics of a clone, XP-FR2, were extensively analyzed. The XP-FR2 cells expressed high level of XPF protein as well as ERCC1 protein, although their parental XP-F cells ...

Abstract Women live longer than men worldwide – and also show cognitive resilience in many aging populations. One major source of biologic difference between the sexes is that females have two X chromosomes males one. This sex chromosome complement causes unique X-derived mechanisms are sex-specific. In mammalian development, one randomly inactivates XX cells. mosaics with active each cell bein...

Wir berichten über unsere Erfahrungen beim versuchsweisen Einsatz von XP in Software-Entwicklungspraktika an der Universität. Mit der Projektplanung nach XP waren unsere wenig programmiererfahrenen TeilnehmerInnen teilweise überfordert, aber insbesondere die Konzepte von XP zur Verbesserung des Codes und der Kommunikation im Team haben sich sehr bewährt. Auf diese wollen wir auch in modellbasie...

In this paper we discuss several features of XP we have used in developing curricula and courses at Duke University and the University of Northern Iowa. We also discuss those practices of XP that we teach as part of the design and implementation process we want students to practice as they develop programming expertise and experience. In theory the academic study of programming and software dev...

In this paper we present a simple management framework built on the classic model of management functions. We apply this framework to Extreme Programming(XP), a new software engineering process model that has attracted much attention recently. We identify a number of issues where XP might benefit from a review of research done in other disciplines, e.g. management science. XP is often character...

background: in most mammals, sex is determined at the beginning of gestation by the constitution of the sex chromosomes, xy in males and xx in females. case: here we report an interesting case characterized by ambiguous genitalia and ovotestis in a newborn carrying an apparently female karyotype (46 xx). array comparative genomic hybridization (array-cgh) revealed an unbalanced rearrangement re...

Xeroderma pigmentosum (XP) is a devastating disease associated with dramatic skin cancer proneness. XP cells are deficient in nucleotide excision repair (NER) of bulky DNA adducts including ultraviolet (UV)-induced mutagenic lesions. Approaches of corrective gene transfer in NER-deficient keratinocyte stem cells hold great hope for the long-term treatment of XP patients. To face this challenge,...