Non-homologous end joining (NHEJ) repairs DNA double-strand breaks generated by DNA damage and also those occurring in V(D)J recombination in immunoglobulin and T cell receptor production in the immune system. In NHEJ DNA-PKcs assembles with Ku heterodimer on the DNA ends at double-strand breaks, in order to bring the broken ends together and to assemble other proteins, including DNA ligase IV ...

The repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic integrity and viability for all organisms. Mammals have evolved at least two genetically discrete ways to mediate DNA DSB repair: homologous recombination (HR) and non-homologous end joining (NHEJ). In mammalian cells, most DSBs are preferentially repaired by NHEJ. Recent work has demonstrated that NHEJ con...

Non-homologous end joining (NHEJ) is critical for the maintenance of genetic integrity and DNA double-strand break (DSB) repair. NHEJ is regulated by a series of interactions between core components of the pathway, including Ku heterodimer, XLF/Cernunnos, and XRCC4/DNA Ligase 4 (Lig4). However, the mechanisms by which these proteins assemble into functional protein-DNA complexes are not fully u...

A reanalysis of the X-ray luminosities of clusters of galaxies in the EMSS sample with 0.3<z<0.6. ABSTRACT The X-ray luminosities of the Einstein Extended Medium Sensitivity Survey (EMSS) clusters of galaxies with redshifts 0.3< z <0.6 are remeasured using ROSAT PSPC data. It is found that the new luminosities are on average 1.18±0.08 times higher than previously measured but that this ratio de...

The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are first recognized by Ku, which then interacts with other NHEJ proteins to improve their affinity at DNA ends. These include DNA-PKcs and Artemis for trimming the DNA ends; DNA polymerase μ and λ to add nucleotides; and the DN...

In this paper, I revisit the constraints obtained by several authors (Reichart et al. 1999; Eke et al. 1998; Henry 2000) on the estimated values of Ω m , n and σ 8 in the light of recent theoretical developments: 1) new theoretical mass functions (Sheth & Tormen 1999, Sheth, Mo & Tormen 2001, Del Popolo 2002b); 2) a more accurate mass-temperature relation, also determined for arbitrary Ω m and ...

In this chapter we use particle filtering methods to estimate volatility and examine volatility dynamics for three financial time series during the early part of the current credit crisis. We compare estimates from a pure stochastic volatility model, a stochastic volatility model with jumps and a Garch model to each other and to the market volatilities implied by actual option prices. Our three...

Using results of Chandra observations of old stellar systems in eleven nearby galaxies of various morphological types and the census of LMXBs in the Milky Way, we study the population of low mass X-ray binaries and their relation to the mass of the host galaxy. We show that the azimuthally averaged spatial distribution of the number of LMXBs and, in the majority of cases, of their collective lu...

DNA double-strand breaks (DSBs) are biologically one of the most important cellular lesions and possess varying degrees of chemical complexity. The notion that the repairability of more chemically complex DSBs is inefficient led to the concept that the extent of DSB complexity underlies the severity of the biological consequences. The repair of DSBs by non-homologous end joining (NHEJ) has been...

In this paper, I revisit the constraints obtained by several authors (Reichart et al. 1999; Eke et al. 1998; Henry 2000) on the estimated values of Ωm, n and σ8 in the light of recent theoretical developments: 1) new theoretical mass functions (Sheth & Tormen 1999, Sheth, Mo & Tormen 2001, Del Popolo 2002b); 2) a more accurate mass-temperature relation, also determined for arbitrary Ωm and ΩΛ (...