seventy seven adult large mixed breed dogs of either sex were included in this study. the animals were randomly divided into four groups and received the following drug combinations intramuscularly: group 1 xylazine (0.5 mg/kg) and acepromazine (0.05 mg/kg), group 2 xylazine (0.8 mg/kg) and acepromazine (0.03 mg/kg), group 3 xylazine (0.3 mg/kg) and acepromazine (0.08 mg/kg) and group 4 xylazin...

We have recently developed an experimental approach to study central opioid control of renal function in anesthetized rats. This model system uses the intravenous infusion of the α2-agonist xylazine to enhance basal levels of urine flow rate and urinary sodium excretion in ketamine-anesthetized rats. This study examined the contribution of central and peripheral α2-adrenergic receptor mechanism...

The effects of acute exposure to 3 different temperature and humidity conditions on arterial blood-gas and acid-base balance in goats were investigated after intravenous bolus administration of xylazine at a dose of 0.1 mg/kg. Significant (P<0.05) changes in the variables occurred under all 3 environmental conditions. Decreases in pH, partial pressure of oxygen and oxyhaemoglobin saturation wer...

Deep anesthesia is commonly used as a model of slow-wave sleep (SWS). Ketamine-xylazine anesthesia reproduces the main features of sleep slow oscillation: slow, large-amplitude waves in field potential, which are generated by the alternation of hyperpolarized and depolarized states of cortical neurons. However, direct quantitative comparison of field potential and membrane potential fluctuation...

Xylazine, a veterinary sedative, has been found as an adulterant of heroin in street drugs in Puerto Rico. It was found in combination with free morphine and 6-acetylmorphine, codeine, cocaine and benzoylecgonine in postmortem cases at the Puerto Rico Institute of Forensic Sciences (PRIFS). Xylazine is not approved for human use because it has been proven harmful. Currently, three separate anal...

OBJECTIVE To evaluate the effect of the mode of mechanical ventilation (MV) on the dose of intravenous anesthetic during 3 hours of ketamine/xylazine anesthesia. STUDY DESIGN Prospective laboratory study. ANIMALS Sixty-one adult male New Zealand White rabbits. METHODS Rabbits were anesthetized (ketamine/xylazine 35 + 5 mg kg(-1), IM), the trachea was intubated and randomized to four group...

Objective- To compare the effects of xylazine-ketamine and xylazine-thiopental on cardiac rhythm indogs.Design- Experimental study.Animals- 15 mixed-bred, adult dogs of either sex.Procedures- Following premedication with xylazine HCI, either ketarnine HCI or sodium thiopentalwere administered to dogs. Cardiac rhythm was evaluated before as well as 15,30,45, and 60 minutes and3 days after induct...

the objective of this study was to evaluate several drug combinations for intraperitoneal anaesthesia in laboratory rats. following dose determination of anaesthetics in a pilot study, 45 healthy adult male rats were randomly assigned in 9 treatment groups and received propofol (alone or in combination with xylazine, midazolam, or ketamine) or ketamine (in combination with xylazine, midazolam, ...