Greenland ice-core δ(18)O-temperature reconstructions suggest a dramatic cooling during the Younger Dryas (YD; 12.9-11.7 ka), with temperatures being as cold as the earlier Oldest Dryas (OD; 18.0-14.6 ka) despite an approximately 50 ppm rise in atmospheric CO(2). Such YD cooling implies a muted Greenland climate response to atmospheric CO(2), contrary to physical predictions of an enhanced high...

The effects of the Younger Dryas (YD) fluctuation on Late Pleistocene hunter-gatherers' settlement and subsistence systems in southern Alps are poorly known. This is primarily due to scarcity archaeological sites dating from YD, contrast with extensive evidence available lateglacial interstadial early Holocene. Here, we present initial stratigraphic, chronologic geoarchaeological data collected...

Wittke et al. (1) present evidence of a major cosmic impact at the onset of the Younger Dryas (YD) episode, including some markers found in the top of the well-known Usselo marker horizon (UH). This finding is contrary to our extensive radiocarbon dating effort from this horizon (2), which shows that the UH at Aalsterhut postdates the onset of the YD. Furthermore, Wittke et al. (1) misinterpret...

It has been previously suggested that abnormal yolk sac characteristics and slow embryonic foetal heart rate are associated with poor gestational outcome and these parameters can be used to assess foetal viability in first trimester of pregnancies. However there is paucity of evidence in Indian medical literature. The purpose of present study was to examine the role of yolk sac characteristics ...

Yolk/shell capsules containing a volume/hydrophobicity transformable core and an ultra-thin silica shell have been prepared. When an external magnetic field induced the temperature, the cores exhibit a significant triggering size shrinkage and the diameter decreases more than 10 times, causing solid shells destruction and physical collapse, leading to drug burst release.

CKD-602 (7-[2-(N-isopropylamino) ethyl]-(20S)-camptothecin, belotecan) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor that has been shown to exert a clinical anticancer effect on various types of tumor. In the present study, the anticancer effects of CKD-602 on the following three human oral squamous cell carcinoma (OSCC) cell lines originating from Korean ca...

The effects of la,25-dihydrox>vitamin D., (YD3) on proliferation, differentiation, and macromolecular synthesis in the new Philadelphia chromosome-positive chronic myelogenous leukemia cell line, RVVLeu4, were investigated. Binding of ['11]VI>, was saturable, with approxi mately 2000-3000 sites/cell, and half-maximal binding occurring at 0.210.33 nM. Treatment of R\VLeu-4 cells with VDj induced...

Structurally specific very low density lipoprotein (VLDL) particles are presumed to redirect VLDL uptake during yolk deposition. Egg production is an energy intensive process, but energy excess negatively affects egg production. This study sought to determine whether overfeeding changed hen lipoprotein profiles, and if so, whether changes were related to egg production. Overfeeding caused 33% o...

BACKGROUND Hydrosalpinx fluid may be toxic to sperm and early embryo growth. Information concerning the effect of hydrosalpinx fluid on embryo development during organogenesis is lacking. METHODS Rat embryos at gestational day 9.5 were cultured for 48 h with 80% rat serum and 20% of either hydrosalpinx fluid (study group) or lactated Ringer's solution (control group). Embryos were scored for ...

Reconstructing the spatial and temporal response of mountain glaciers to rapid climate change in past provides access effects current change. Yet, variability glacier fluctuations is not fully understood. In this study, we focus on timing European Alps during Younger Dryas/Early Holocene (YD/EH) transition. an effort elucidate whether were synchronous period, present a new chronology Alpine Tal...