Zafirlukast (ZAF) is a leukotriene receptor antagonist used in the treatment of chronic asthma. In this study, a simple and sensitive reversed-phase, high-performance liquid chromatographic method was developed for the determination of ZAF in pharmaceutical formulations and human plasma. Piribedil was used as an internal standard. Analysis was carried out on a Nucleosil C18 100 A (150 mm x 4.6 ...

One of the challenges in the development of methionine aminopeptidase (MetAP) inhibitors as antibacterial and anticancer agents is to define the metal ion actually used by MetAP in vivo and to discover MetAP inhibitors that can inhibit the metalloform that is relevant in vivo. Two distinct classes of novel nonpeptidic MetAP inhibitors that are not only potent but also highly selective for eithe...

Chiral alkyl or amido yttrium complexes were prepared from N-silyl- or N-cyclopentyl-substituted binaphthylamido ligands. According to the synthetic procedure, these complexes could be obtained in their neutral form or as heterobimetallic complexes in the presence of 1 equiv. LiCl. These new species were characterized by IR and NMR spectroscopies, elemental analyses and some of them by X-ray di...

Abbreviations used: DMSO, Dimethyl sulfoxide; E. coli, Escherichia coli; FP, 15 Fluorescence Polarization; LB, Luria-Bertani; MDR-TB, Multi-Drug Resistant 16 Tuberculosis; MALDI, Matrix-Assisted Laser Desorption/Ionization; MIC, 17 Minimum Inhibitory Concentration; M. smegmatis, Mycobacterium smegmatis; 18 Mtb, Mycobacterium tuberculosis; MTT, (3-(4,5-Dimethylthiazol-2-yl)-2,519 diphenyltetrazo...

A 42-year-old man presented with a 10-year history of atopic dermatitis that was refractory to treatment with UV light, oral antihistamines, and high-potency topical corticosteroids. On presentation, he denied any other medical problems and was taking no medicines. His condition improved with the use of cyclosporine; however, this regimen was discontinued secondary to transaminitis due to hepat...