the study describes the synthesis and characterization of zinc(ii) minoxidil nanocomposite (1). the reaction between zinc(ii) acetate, minoxidil, {c9h15n5o=minoxidil=(2,4-diamino-6-piperidine-1-yl) pyrimidine n-oxide)} as a ligand and ki as bridging agent, in methanol at 60°c leads to the formation of nano-sized zn(ii) minoxidil nanocomposite, 1. characterization of (1) was carried out by eleme...

Senescence, a hallmark of mammalian aging, is associated with the onset and progression of cardiovascular disease. Angiotensin II (Ang II) signaling and zinc homeostasis dysfunction are increased with age and are linked to cardiovascular disease, but the relationship among these processes has not been investigated. We used a model of cellular senescence induced by Ang II in vascular smooth musc...

A zinc(II) complex of polypyazole containing ligand namely, [Tp*ZnCl] (Zn1) {Tp* = tris(3,5-dimethylpyrazolyl)borate}, along with its bound hydroxo [Tp*Zn–OH] (Zn2) were synthesized and characterized by FT-IR, Raman, 1H NMR techniques elemental analysis. In alkaline solution (0.1 M KOH), the Zn2 modified glassy carbon (GC), namely GC–Zn2, was investigated as a molecular electrocatalyst for hydr...

Histidine 64 in human carbonic anhydrase II (HCA II) functions in the catalytic pathway of CO(2) hydration as a shuttle to transfer protons between the zinc-bound water and bulk water. Catalysis of the exchange of (18)O between CO(2) and water, measured by mass spectrometry, is dependent on this proton transfer and was decreased more than 10-fold for H64A HCA II compared with wild-type HCA II. ...

A new copper(II) complex with a (bdpg-His) ligand was prepared and its structural properties were investigated both in crystalline and in solution states; (bdpg-His) = N,N-bis(2-pyridylmethyl)carnosine methylester. In the solid state, the complex has a dimeric structure, but in solution it partially dissociates into monomeric species, which have an imidazole moiety as an anchor group. This comp...

To obtain rich in organic forms of zinc extracts of Lentinus edodes, possessing putative higher immunostimulating properties than actually used, mycelia were cultivated in zinc(II) enriched media. Culture media were enriched in zinc in concentration ranging from 0 to 90 microg mL(-1), added to the medium before inoculation. Total zinc concentration in submerged cultivated mycelial biomass has b...

An anthracene-bridged dinuclear zinc(ii)-dipicolylamine complex was found to show high selectivity for ADP with a significant fluorescence enhancement over ATP, PPi and other common analytes in 100% aqueous solution. This complex can be used for fluorescence detection of ADP in living cells and for monitoring the activity of kinases.

Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised. Gadolinium(III) complexes of these three ligands have been prepared as potential monomers for the synthesis of polymeric MRI contrast agents. To assess the potential of these monomers as MRI contrast age...

The extraction rates of cadmium(II) and zinc(II) with dithizone (H2dz) in the presence of nitrilotriacetic acid (NTA) were measured, and the possible kinetic separation of cadmium(II) from zinc(II) was investigated. Upon the addition of NTA, the difference in the extraction rate between cadmium(II) and zinc(II) became large. Based on the observed rate constant under the condition [NTA] = 1 x 10...

The levels of carbonic anhydrase I and II isozymes in human erythrocytes were determined using the single radial immunodiffusion method in 53 patients (29 males, 24 females) under chronic hemodialysis, and zinc concentration in erythrocytes were also determined. Both carbonic anhydrase. I and II levels and zinc concentration in erythrocytes were observed to be significantly increased in chronic...