نتایج جستجو برای: zinc toxicity
تعداد نتایج: 189559 فیلتر نتایج به سال:
Toxicity is a very very important aspect of any biochemical or pharmacological experiment. Either we develop any metallo drug or a metal suppliment measurement of toxicity of that particular substance and parent substances is very important. The toxicity of a substance can be measured in many ways. Generally it is estimated on the test animal, viz. rats, mice, cat and other animal models. Acute...
Mitochondria have been identified as targets of the neurotoxic actions of zinc, possibly through decreased mitochondrial energy production and increased reactive oxygen species accumulation. It has been hypothesized that impairment of mitochondrial trafficking may be a mechanism of neuronal injury. Here, we report that elevated intraneuronal zinc impairs mitochondrial trafficking. At concentrat...
We studied the toxicity of sediments downstream of lead-zinc mining areas in southeast Missouri, using chronic sediment toxicity tests with the amphipod, Hyalella azteca, and pore-water toxicity tests with the daphnid, Ceriodaphnia dubia. Tests conducted in 2002 documented reduced survival of amphipods in stream sediments collected near mining areas and reduced survival and reproduction of daph...
Intracellular zinc is thought to be available in a cytosolic pool of free or loosely bound Zn(II) ions in the micromolar to picomolar range. To test this, we determined the mechanism of zinc sensors that control metal uptake or export in Escherichia coli and calibrated their response against the thermodynamically defined free zinc concentration. Whereas the cellular zinc quota is millimolar, fr...
The clinical manifestations of zinc deficiency and anorexia nervosa are remarkably similar, and a number of studies have demonstrated that there may be a positive correlation between zinc therapy and the rate of recovery of anorexia nervosa patients. However, because of the different interpretations of the results of these studies, the use of zinc supplementation varies. This article examines t...
This volume is the publication of the proceedings of a conference held in Detroit, Michigan, in 1980. It is unfortunate that the publication was delayed nearly two years from the time of the meeting. However, knowledge is not accumulating quite as rapidly in this field as it is in some others, so the delay is not seriously deleterious. Over the past two decades knowledge of trace elements has i...
This volume is the publication of the proceedings of a conference held in Detroit, Michigan, in 1980. It is unfortunate that the publication was delayed nearly two years from the time of the meeting. However, knowledge is not accumulating quite as rapidly in this field as it is in some others, so the delay is not seriously deleterious. Over the past two decades knowledge of trace elements has i...
Mycobacterium tuberculosis thrives within macrophages by residing in phagosomes and preventing them from maturing and fusing with lysosomes. A parallel transcriptional survey of intracellular mycobacteria and their host macrophages revealed signatures of heavy metal poisoning. In particular, mycobacterial genes encoding heavy metal efflux P-type ATPases CtpC, CtpG, and CtpV, and host cell metal...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید