نتایج جستجو برای: (alfa

تعداد نتایج: 18590  

Journal: :Reproductive biology and endocrinology : RB&E 2008
Michael Alper Randal Meyer Chris Dekkers Diego Ezcurra Joan Schertz Eduardo Kelly

BACKGROUND The current study was designed to determine if follitropin alfa (recombinant human follicle-stimulating hormone; r-hFSH) and lutropin alfa (recombinant human luteinizing hormone; r-hLH) biopotencies were unchanged by reconstituting in sterile water for injection and mixing prior to injection. METHODS The biopotencies of r-hFSH and r-hLH were determined following injection of female...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006
Carlos Lucas Fernando Carrera Cristina Jorge Helena Boquinhas Maria Joao Pais

BACKGROUND Anaemia is aggravated by the coexistence of chronic kidney disease (CKD) in patients infected with human immunodeficiency virus (HIV). Darbepoetin alfa effectively alleviates CKD-associated anaemia with less frequent dosing than recombinant human erythropoietin (EPO). The current study aimed to determine the efficacy, safety and cost-effectiveness of darbepoetin alfa compared with er...

Journal: :Annals of hepatology 2003
Francisco Bosques-Padilla Rafael Trejo-Estrada Octaivio Campollo-Rivas Carlos Cortez-Hernández Margarita Dehesa-Violante Héctor Maldonado-Garza Rául Pérez-Gómez Armando Cabrera-Valdespino

Treatment with polyethylene glycol-modified interferon alfa-2a (peginterferon) alone produces significantly higher sustained antiviral responses than treatment with interferon alfa-2a alone in patients with chronic hepatitis C virus (HCV) infection. We compared the efficacy and safety of peginterferon alfa-2a plus ribavirin, interferon alfa-2b plus ribavirin, and peginterferon alfa-2a alone in ...

Journal: :Journal of hepatology 2002
Michael W Fried Mitchell L Shiffman K Rajender Reddy Coleman Smith George Marinos Fernando L Gonçales Dieter Häussinger Moises Diago Giampiero Carosi Daniel Dhumeaux Antonio Craxi Amy Lin Joseph Hoffman Jian Yu

BACKGROUND Treatment with peginterferon alfa-2a alone produces significantly higher sustained virologic responses than treatment with interferon alfa-2a alone in patients with chronic hepatitis C virus (HCV) infection. We compared the efficacy and safety of peginterferon alfa-2a plus ribavirin, interferon alfa-2b plus ribavirin, and peginterferon alfa-2a alone in the initial treatment of chroni...

2016
José Luis Molinuevo Nina Gramunt Juan Domingo Gispert Karine Fauria Manel Esteller Carolina Minguillon Gonzalo Sánchez-Benavides Gema Huesa Sebastián Morán Rafael Dal-Ré Jordi Camí

INTRODUCTION The preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project, including the ALFA registry and parent cohort and the nested ALFA+ cohort study. METHODS The ALFA parent cohort baseline visit included full cognitive evaluation, lifestyle habits questionnaires...

Journal: :Hepatology 2001
K L Lindsay C Trepo T Heintges M L Shiffman S C Gordon J C Hoefs E R Schiff Z D Goodman M Laughlin R Yao J K Albrecht

This international, randomized, active-controlled, parallel-group, double-blind dose-finding study compared peginterferon alfa-2b (PegIntron) to interferon alfa-2b for the initial treatment of compensated chronic hepatitis C. We randomly assigned 1,219 subjects to receive either the standard three-times-weekly (TIW) interferon alfa-2b dose (3 MIU) or the once-weekly (QW) peginterferon alfa-2b (...

Journal: :The New England journal of medicine 2009
John G McHutchison Eric J Lawitz Mitchell L Shiffman Andrew J Muir Greg W Galler Jonathan McCone Lisa M Nyberg William M Lee Reem H Ghalib Eugene R Schiff Joseph S Galati Bruce R Bacon Mitchell N Davis Pabak Mukhopadhyay Kenneth Koury Stephanie Noviello Lisa D Pedicone Clifford A Brass Janice K Albrecht Mark S Sulkowski

BACKGROUND Treatment guidelines recommend the use of peginterferon alfa-2b or peginterferon alfa-2a in combination with ribavirin for chronic hepatitis C virus (HCV) infection. However, these regimens have not been adequately compared. METHODS At 118 sites, patients who had HCV genotype 1 infection and who had not previously been treated were randomly assigned to undergo 48 weeks of treatment...

2012
Nikolai Pfender Ralf Lucassen Nadine Offermann Johannes Schulte-Pelkum Margrit Fooke Thilo Jakob

Background. The Allergy Lateral Flow Assay (ALFA) is a novel rapid assay for the detection of sIgE to allergens. The objective of this study is the evaluation of ALFA for the detection of sIgE to bee venom (BV) and wasp venom (WV) in insect venom allergic patients. Methods. Specific IgE to BV and WV was analyzed by ALFA, ALLERG-O-LIQ, and ImmunoCAP in 80 insect venom allergic patients and 60 co...

2015
Izumi Sato Takuro Shimbo Yohei Kawasaki Naohiko Masaki

PURPOSE We aimed to compare the rates of sustained virologic response (SVR) achieved with peginterferon (PEG-IFN) alfa-2a and alfa-2b in combination with ribavinin (RBV) for chronic hepatitis C, using a large database of hepatitis cases to improve the generalizability of these results. METHODS We identified patients with chronic hepatitis C who were treated with PEG-IFN alfa-2a or alfa-2b and...

Journal: :The New England journal of medicine 2000
E J Heathcote M L Shiffman W G Cooksley G M Dusheiko S S Lee L Balart R Reindollar R K Reddy T L Wright A Lin J Hoffman J De Pamphilis

BACKGROUND Chronic hepatitis C virus (HCV) infection in patients with cirrhosis is difficult to treat. In patients with chronic hepatitis C but without cirrhosis, once-weekly administration of interferon modified by the attachment of a 40-kd branched-chain polyethylene glycol moiety (peginterferon alfa-2a) is more efficacious than a regimen of unmodified interferon. We examined the efficacy and...

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