نتایج جستجو برای: (h5)6

تعداد نتایج: 79  

Journal: :The Journal of clinical investigation 2012
Philana Ling Lin Jes Dietrich Esterlina Tan Rodolfo M Abalos Jasmin Burgos Carolyn Bigbee Matthew Bigbee Leslie Milk Hannah P Gideon Mark Rodgers Catherine Cochran Kristi M Guinn David R Sherman Edwin Klein Christopher Janssen JoAnne L Flynn Peter Andersen

It is estimated that one-third of the world's population is infected with Mycobacterium tuberculosis. Infection typically remains latent, but it can reactivate to cause clinical disease. The only vaccine, Mycobacterium bovis bacillus Calmette-Guérin (BCG), is largely ineffective, and ways to enhance its efficacy are being developed. Of note, the candidate booster vaccines currently under clinic...

2018
Annalisa Ciabattini Elena Pettini Fabio Fiorino Simone Lucchesi Gabiria Pastore Jlenia Brunetti Francesco Santoro Peter Andersen Luisa Bracci Gianni Pozzi Donata Medaglini

The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting. Here, we investigated the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial vaccine antigen. C57BL/6 mice were primed with the chimeric vaccine antigen H...

2015
Annalisa Ciabattini Gennaro Prota Dennis Christensen Peter Andersen Gianni Pozzi Donata Medaglini

The design of heterologous prime-boost vaccine combinations that optimally shape the immune response is of critical importance for the development of next generation vaccines. Here, we tested different prime-boost combinations using the tuberculosis vaccine antigen H56 with CAF01 or CpG ODN 1826 adjuvants, administered by the parenteral and nasal routes. Using peptide-MHC class II tetramers, an...

2017
Anouk C. M. Platteel Natalie E. Nieuwenhuizen Teresa Domaszewska Stefanie Schürer Ulrike Zedler Volker Brinkmann Alice J. A. M. Sijts Stefan H. E. Kaufmann

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global threat. The only approved vaccine against TB, Mycobacterium bovis bacillus Calmette-Guérin (BCG), provides insufficient protection and, being a live vaccine, can cause disseminated disease in immunocompromised individuals. Previously, we found that intradermal cDNA tattoo immunization with cDNA of tetanus toxoid fra...

2016
Rolf Billeskov Esterlina V. Tan Marjorie Cang Rodolfo M. Abalos Jasmin Burgos Bo Vestergaard Pedersen Dennis Christensen Else Marie Agger Peter Andersen

The search for new and improved tuberculosis (TB) vaccines has focused on IFN-γ both for selecting antigens and for evaluating vaccine delivery strategies. The essential role of IFN-γ in endogenous host protection is well established, but it is still uncertain whether this also holds true for vaccine protection. Here we evaluate the H56 fusion protein vaccine as a BCG booster in a non-human pri...

2018
Thomas Lindenstrøm Albanus Moguche Mie Damborg Else Marie Agger Kevin Urdahl Peter Andersen

Despite inducing strong T cell responses, Mycobacterium tuberculosis (Mtb) infection fails to elicit protective immune memory. As such latently infected or successfully treated Tuberculosis (TB) patients are not protected against recurrent disease. Here, using a mouse model of aerosol Mtb infection, we show that memory immunity to H56/CAF01 subunit vaccination conferred sustained protection in ...

2011
Subhayu Bandyopadhyay Javed Younas

This paper finds that political freedom has a significant and non-linear effect on domestic terrorism, but this effect is not significant in the case of transnational terrorism. Some of our other novel findings are that while geography and fractionalization may limit a county’s ability to curb terrorism, the presence of strong legal institutions deters it. JEL classification codes: D74, H56

2016
Annalisa Ciabattini Elena Pettini Fabio Fiorino Gabiria Pastore Peter Andersen Gianni Pozzi Donata Medaglini

Adjuvants contribute to enhancing and shaping the vaccine immune response through different modes of action. Here early biomarkers of adjuvanticity after primary immunization were investigated using four different adjuvants combined with the chimeric tuberculosis vaccine antigen H56. C57BL/6 mice were immunized by the subcutaneous route with different vaccine formulations, and the modulation of...

Journal: :American Economic Journal: Macroeconomics 2022

We show that during the Great Recession, more-flexible sectors paid lower sectoral bond spreads. rationalize this fact with a model input-output linkages, heterogeneous elasticities, and binding working capital constraints in use of intermediates. difference flexibility between upstream downstream is key for determining role linkages amplifying or mitigating distortions. Calibrating to US econo...

2003
Todd Sandler Walter Enders

This paper indicates how economic analysis can be applied for enlightened policy making with respect to transnational terrorism. Both theoretical tools (e.g., game theory and utilitymaximizing models) and empirical techniques (e.g., time series and spectral analysis) are used to put modern-day terrorism into perspective and to suggest policy responses. From hostage negotiations to the installat...

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