نتایج جستجو برای: α agonist

تعداد نتایج: 212440  

Journal: :مجله علوم اعصاب شفای خاتم 0
vida naderi neuroscience research center, kerman university of medical sciences, kerman, iran. mohammad khaksari physiology research center, kerman university of medical sciences, kerman, iran. fatemeh maghool physiology research center, kerman university of medical sciences, kerman, iran.

estrogen (e2) has neuroprotective effects on blood-brain-barrier (bbb) after traumatic brain injury (tbi). in order to investigate the roles of estrogen receptors (ers) in these kind of effects, er-α antagonist (mpp) and, er-β antagonist (phtpp), or non-selective estrogen receptors antagonist (ici 182780) were administered as regulators of cns cytokines levels and neuroinflammation after tbi. m...

Journal: :razavi international journal of medicine 0
habib yaribeygi department of physiology and biophysics, school of medicine, baqiyatallah university of medical sciences, tehran, ir iran mohammad taghi mohammadi department of physiology and biophysics, school of medicine, baqiyatallah university of medical sciences, tehran, ir iran; department of physiology and biophysics, school of medicine, baqiyatallah university of medical sciences, tehran, ir iran. tel/fax: +98-2126127257; +98-9127713583, fax: +98-2126127257

conclusions our findings indicate that fenofibrate (ppar-α agonist) is able to prevent dn progression and improve kidney performance during chronic uncontrolled hyperglycemia possibly through increase in no bioavailability of kidney. results fenofibrate did not change the blood glucose of normal or diabetic rats. diabetes increased the proteinuria (82%) and blood creatinine of diabetic rats (4....

2017
Goh Murayama Nanako Furusawa Asako Chiba Ken Yamaji Naoto Tamura Sachiko Miyake

BACKGROUND Interferon-α (IFN-α) is increased and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are the main producer of IFN-α, but their IFN-α producing capacity has been shown to be unchanged or reduced when stimulated with a Toll-like receptor 9 (TLR9) agonist in patients with SLE compared to in healthy individuals. In t...

Journal: :Cells 2021

Stroke is the third leading cause of mortality in women and it kills twice as many breast cancer. A key role pathophysiology stroke plays disruption blood–brain barrier (BBB) within neurovascular unit. While estrogen induces vascular protective actions, its influence on remains unclear. Moreover, experiments assessing impact endothelial cells to induce integrity are non-conclusive. Since pericy...

Asthma is a disease characterized by spontaneous contraction of the airways in response to a wide variety of endogenous and exogenous stimuli. Many asthma models are used to mimic the human asthma model in the literature. In order to better understand the role of the cannabinoid (CB) 2 receptor in the ovalbumin (OVA)-induced asthma model, a combination of both selective CB2 agonist (AM1241) and...

Journal: :Journal of hypertension and management 2021

Intradialysis hypotension (IDH) is the most common complication during hemodialysis procedure. Midodrine, an oral α-1 adrenergic agonist, commonly used to prevent IDH. However, limited data available demonstrate midodrine effectiveness in prevention of IDH high-risk patients.

Asthma is a disease characterized by spontaneous contraction of the airways in response to a wide variety of endogenous and exogenous stimuli. Many asthma models are used to mimic the human asthma model in the literature. In order to better understand the role of the cannabinoid (CB) 2 receptor in the ovalbumin (OVA)-induced asthma model, a combination of both selective CB2 agonist (AM1241) and...

Journal: :Diabetic Nephropathy 2022

Abstract Background The effects of vitamin D receptor (VDR) agonist paricalcitol on the podocyte injury induced by high glucose (HG) were investigated in conditioned immortalized mouse podocytes (MPC-5). Methods (1) Grouped according to different concentrations: normal group (NG): 5.6 mmol/L glucose; HG stimulation group: 25 (25HG); osmotic control (NG+M): + 19.4 D-mannitol. expression levels V...

2015
Corrie J. B. daCosta Chris R. Free Steven M. Sine

α-Bungarotoxin (α-Btx) binds to the five agonist binding sites on the homopentameric α7-acetylcholine receptor, yet the number of bound α-Btx molecules required to prevent agonist-induced channel opening remains unknown. To determine the stoichiometry for α-Btx blockade, we generate receptors comprised of wild-type and α-Btx-resistant subunits, tag one of the subunit types with conductance muta...

2018
Tamiris Lima Rachid Flavia Maria Silva-Veiga Francielle Graus-Nunes Isabele Bringhenti Carlos Alberto Mandarim-de-Lacerda Vanessa Souza-Mello

BACKGROUND AND AIMS Obesity compromises adipocyte physiology. PPARs are essential to adipocyte plasticity, but its isolated role in the browning phenomenon is not clear. This study aimed to examine whether activation of PPAR-α or PPAR-β/δ could induce beige cell depots in the subcutaneous white adipose tissue of diet-induced obese mice. MATERIAL AND METHODS Sixty animals were randomly assigne...

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