in an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (pocl3). the synthesized compounds were identified by 1h-nmr, 13c-nmr, ft-ir spectroscopic techniques and elemental analysis. all products were...

it is believed that the inhibition of carbohydrate hydrolyzing enzymes including α-amylase and α-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. in our study four flavonoids, namely luteoli...

This study analyzed the inhibition activity of Swietenia mahagoni seeds extract on α-glucosidase and α-amylase enzymes inhibition assays.  Swietenia mahagoni seeds were extracted by using Supercritical Carbon Dioxide (SC-CO2) extraction at pressures of 20- 30 MPa and temperatures of 40- 60°C.  The oil yields obtained were analyzed with α- glucosidase and α- amylase enzymes inhibition assays.  A...

the side effects associated with the usage of synthetic antidiabetic drugs make it imperative to search for alternative drugs from medicinal plants. therefore, this study was aimed at evaluating the α-amylase and α-glucosidase inhibitory potential of calotropis procera leaf, as well as its possible mode of inhibiting these enzymes. acetone, aqueous and ethanolic extracts of c. procera leaf was ...

The side effects associated with the usage of synthetic antidiabetic drugs make it imperative to search for alternative drugs from medicinal plants. Therefore, this study was aimed at evaluating the α-amylase and α-glucosidase inhibitory potential of Calotropis procera leaf, as well as its possible mode of inhibiting these enzymes. Acetone, aqueous and ethanolic extracts of C. procera leaf was ...

The side effects associated with the usage of synthetic antidiabetic drugs make it imperative to search for alternative drugs from medicinal plants. Therefore, this study was aimed at evaluating the α-amylase and α-glucosidase inhibitory potential of Calotropis procera leaf, as well as its possible mode of inhibiting these enzymes. Acetone, aqueous and ethanolic extracts of C. procera leaf was ...

background: diabetes mellitus is a chronic disease. decreasing postprandial hyperglycemia by retarding glucose absorption through inhibiting carbohydrates digesting enzymes (α-amylase and α-glucosidase) is one of many approaches used for the management of this disease. this study was aimed at evaluating the normoglycaemic potential of helianthus annuus leaf. methods: the effect of the in vitro ...

the present study was designed to determine the effects of the essential oil of laurusnobilis l. (lauraceae) and its three main components on α-glucosidase and reactive oxygenspecies scavenging activity. the chemical composition of the essential oil from laurus nobilisl. leaves was analyzed by gc/gc-ms and resulted in the identification of 29 compounds,representing 99.18% of the total oil. 1,8-...

in an attempt to develop alternative medicine for the treatment of diabetes and related complications, the antidiabetic potential of the fruits of c rataegus pinnatifida was evaluated. the antidiabetic potential of the methanol (meoh) extract as well as different solvent soluble fractions of the fruits of c . pinnatifida was evaluated via α-glucosidase, protein tyrosine phosphatase 1b (ptp1b), ...

The present study was designed to determine the effects of the essential oil of Laurusnobilis L. (Lauraceae) and its three main components on α-glucosidase and reactive oxygenspecies scavenging activity. The chemical composition of the essential oil from Laurus nobilisL. leaves was analyzed by GC/GC-MS and resulted in the identification of 29 compounds,representing 99.18% of the total oil. 1,8-...