نتایج جستجو برای: β glycerophosphate

تعداد نتایج: 178270  

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014
Weiwei Qiao Li Chen Mingxiang Zhang

OBJECTIVES We investigated the role of miR-205 in the osteogenic differentiation of vascular smooth muscle cells (VSMCs). METHODS Osteogenic differentiation of human aortic smooth muscle cells (HASMCs) was induced by 10 mM β-glycerophosphate (β-GP). Alizarin Red S staining, alkaline phosphatase (ALP) activity and osteocalcin secretion were used to determine osteogenic differentiation of HASMC...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2014
Yun Zhou Jin-Yu Wang Han Feng Cheng Wang Li Li Dan Wu Hong Lei Hao Li Li-Ling Wu

OBJECTIVE Vascular calcification is highly correlated with increased cardiovascular morbidity and mortality. C1q/tumor necrosis factor-related protein-3 (CTRP3) is a newly identified adipokine that plays important roles in cardiovascular system. Here, we investigated the role of CTRP3 in vascular calcification and its underlying mechanism. APPROACH AND RESULTS Adenine-induced chronic renal fa...

Journal: :Cardiovascular research 2012
Rong-Rong Cui Shi-Jun Li Ling-Juan Liu Lu Yi Qiu-Hua Liang Xiao Zhu Guan-Ying Liu Yuan Liu Shan-Shan Wu Xiao-Bo Liao Ling-Qing Yuan Ding-An Mao Er-Yuan Liao

AIMS Medial artery calcification is a common macroangiopathy that initiates from a cell-regulated process similar to osteogenesis. Although the mechanisms governing this process remain unclear, epigenomic regulation by specific microRNAs might play a role in vascular smooth muscle cell (VSMC) calcification. In this study, we aimed to investigate whether miR-204 participates in the regulation of...

2015
Zhu-Ying Xia Yin Hu Ping-Li Xie Si-Yuan Tang Xiang-Hang Luo Er-Yuan Liao Fei Chen Hui Xie

We previously reported that Runx2/miR-3960/miR-2861 regulatory feedback loop stimulates osteoblast differentiation. However, the effect of this feedback loop on the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) remains unclear. Our recent study showed that miR-2861 and miR-3960 expression increases significantly during β-glycerophosphate-induced osteogenic transdiffere...

2015
Jana Lisková Lucie Bačaková Agata L. Skwarczyńska Olga Musial Vitaliy Bliznuk Karel De Schamphelaere Zofia Modrzejewska Timothy E.L. Douglas Kazuo Azuma

Thermosensitive injectable hydrogels based on chitosan neutralized with sodium beta-glycerophosphate (Na-β-GP) have been studied as biomaterials for drug delivery and tissue regeneration. Magnesium (Mg) has been reported to stimulate adhesion and proliferation of bone forming cells. With the aim of improving the suitability of the aforementioned chitosan hydrogels as materials for bone regenera...

Journal: :Molecules 2012
Mingyue Liu Yao Sun Yang Liu Mengtong Yuan Zhihui Zhang Weiping Hu

Dentinogenesis is a necessary prerequisite for dental tissue engineering. One of the steps for dentinogenesis is to obtain large quantities of highly purified odontoblasts. Therefore, we have undertaken an experiment applying different concentrations of β-glycerophosphate (β-GP) to induce the differentiation of dental pulp stem cells (DPSCs) in a long-term 28-day culture. In the meanwhile, we h...

Journal: :Dental materials journal 2012
Kanitsak Boonanantanasarn Kajohnkiart Janebodin Prapan Suppakpatana Tawepong Arayapisit Jit-aree Rodsutthi Panjit Chunhabundit Surintorn Boonanuntanasarn Wanida Sripairojthikoon

This present study investigated the potential of Morinda citrifolia leaf aqueous extract to induce osteogenic differentiation and matrix mineralization of human periodontal ligament (hPDL) cells. Human periodontal ligament cells were cultured in complete medium, ascorbic acid with β-glycerophosphate, or Morinda citrifolia leaf aqueous extract. Morinda citrifolia leaf aqueous extract significant...

Journal: :Proceedings of the Japan Academy, Series B 1985

2014
Emilia Szymańska Katarzyna Winnicka Piotr Wieczorek Paweł Tomasz Sacha Elżbieta Anna Tryniszewska

The combination of an antifungal agent and drug carrier with adjunctive antimicrobial properties represents novel strategy of complex therapy in pharmaceutical technology. The goal of this study was to investigate the unmodified and ion cross-linked chitosan's influence on anti-Candida activity of clotrimazole used as a model drug in hydrogels. It was particularly crucial to explore whether the...

Journal: :International Journal of Applied Pharmaceutics 2023

Rheumatoid arthritis (RA) is one of the diseases autoimmune systemic progressively characterized by inflammation membrane synovial that coating joints. Methotrexate (MTX) and Adalimumab are drugs commonly used in treatment. This study aimed to look at effectiveness safety both either monotherapy a combination them. review article experimental studies with data retrieval retrospectively on datab...

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