نتایج جستجو برای: β-amyloid1-42
تعداد نتایج: 284999 فیلتر نتایج به سال:
Lynx1 regulates synaptic plasticity in the brain by regulating nicotinic acetylcholine receptors (nAChRs). It is not known to which extent Lynx1 can bind to endogenous nAChR subunits in the brain or how this interaction is affected by Alzheimer's disease pathology. We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates α3, α4, α5, α6, α7, β...
Objective: Present study investigates the effect of ethanolic C. tora leaves extract on cognitive function in scopolamine and electroshock induced amnesia in rats. Methods: To explore the potential effect, C. tora extract was screened by administrating three doses (100, 200 and 400 mg/kg) for 14 days using scopolamine-induced amnesia model. The dose having maximum activity was selected (400 mg/...
Although postoperative cognitive dysfunction (POCD) is relatively common in elderly patients who have undergone major surgery, the mechanisms underlying this postoperative complication are unclear. Previously, we have investigated the role of cytokine-mediated hippocampal inflammation in the development of POCD in a rat model. Here, we sought to determine in mice the role of cytokine interleuki...
During the normal aging process, cytoskeletal changes such as a reduction in density or disruption of cytoskeletal components occur that can affect neuronal function. As aging is the biggest risk factor for Alzheimer's disease (AD), this study sought to determine how microtubule (MT) modification influences cellular response upon exposure to β-amyloid1-42 (Aβ1-42), which is implicated in AD. Th...
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