نتایج جستجو برای: β-amyloid1-42

تعداد نتایج: 284999  

Journal: :Neurobiology of Aging 2016
Morten S. Thomsen Maria Arvaniti Majbrit M. Jensen Mikhail A. Shulepko Dmitry A. Dolgikh Lars H. Pinborg Wolfgang Härtig Ekaterina N. Lyukmanova Jens D. Mikkelsen

Lynx1 regulates synaptic plasticity in the brain by regulating nicotinic acetylcholine receptors (nAChRs). It is not known to which extent Lynx1 can bind to endogenous nAChR subunits in the brain or how this interaction is affected by Alzheimer's disease pathology. We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates α3, α4, α5, α6, α7, β...

2015
Rohit Malabade Taranalli Ashok

Objective: Present study investigates the effect of ethanolic C. tora leaves extract on cognitive function in scopolamine and electroshock induced amnesia in rats. Methods: To explore the potential effect, C. tora extract was screened by administrating three doses (100, 200 and 400 mg/kg) for 14 days using scopolamine-induced amnesia model. The dose having maximum activity was selected (400 mg/...

2015
Ayong Tian Hong Ma Rongwei Zhang Wenfei Tan Xiaolong Wang Binyang Wu Jun Wang Chengfu Wan Hemachandra Reddy

Although postoperative cognitive dysfunction (POCD) is relatively common in elderly patients who have undergone major surgery, the mechanisms underlying this postoperative complication are unclear. Previously, we have investigated the role of cytokine-mediated hippocampal inflammation in the development of POCD in a rat model. Here, we sought to determine in mice the role of cytokine interleuki...

2016
Nicole Shamitko-Klingensmith Jonathan W. Boyd Justin Legleiter Robert C. Byrd

During the normal aging process, cytoskeletal changes such as a reduction in density or disruption of cytoskeletal components occur that can affect neuronal function. As aging is the biggest risk factor for Alzheimer's disease (AD), this study sought to determine how microtubule (MT) modification influences cellular response upon exposure to β-amyloid1-42 (Aβ1-42), which is implicated in AD. Th...

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