amyloid-β (aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in alzheimer’s disease pathology.uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Describing routes is an easy everyday task for people who know the environment well. However, strategies exist also for situations where only incomplete knowledge is available. We present a study eliciting verbalized route plans and thinkaloud data from novices and experts who were asked to find and describe routes in a complex building. The spatial descriptions were analyzed relating the level...

Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

In conversation, speakers become more like each other in various dimensions. This phenomenon, commonly called entrainment, coordination, or alignment, is widely believed to be crucial to the success and naturalness of human interactions. We investigate entrainment in four acoustic and prosodic dimensions. We explore whether speakers coordinate with each other in these dimensions over the conver...

In this paper we report on our work on a prototype route navigation dialogue system for use in a vehicle. The system delivers spoken turn-by-turn directions, and has been developed to accept naturally phrased navigation queries, as part of our overall effort to create an in-vehicle information system which delivers information as requested while placing minimal cognitive load on the driver.