نتایج جستجو برای: الگوریتم M8
تعداد نتایج: 23297 فیلتر نتایج به سال:
به‌طور متوسط هر چند سال یک‌بار، یک زلزلۀ بزرگ و مخرب در فلات ایران اتفاق می‌افتد که به‌طور معمول، خسارات زیادی به‌جای می‌گذارد. زلزله‌های وان ترکیه، سراوان و سرپل ذهاب-کرمانشاه، سه زلزلۀ اخیر این منطقه از سال 2011 تا 2017 بوده‌اند. توجه به رفتار پیش‌نشانگری لرزه‌ای با استفاده از الگوریتم‌های پیش‌بینی می‌تواند در کاهش خسارات چنین زلزله‌هایی مؤثر واقع شود. در این مقاله، الگوریتم میان‌مدت پیش‌بینی...
زلزله مورخ 23/10/2011 ترکیه در نزدیکی شهر وان با حدود 600 کشته، باعث خسارات زیادی در شهر‌‌‌های ارجیش، وان، مرادیه و چالدران شد. مطالعه زلزله‌های دستگاهی سده بیستم و تاریخی منطقه نشان داد که منطقه خاور صفحه آناتولی و شمال باختر فلات ایران لرزه‌خیز بوده و مهم‌ترین زلزله اخیر منطقه در سال 24 نوامبر 1976 و در چالدران رخ داده است. در این مقاله مسئله پیش‌بینی زلزله در محدوده باختر فلات ایران و به‌صور...
We studied N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride (M8-B), a selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. In vitro, M8-B blocked cold-induced and TRPM8-agonist-induced activation of rat, human, and murine TRPM8 channels, including those on primary sensory neurons. In vivo, M8-B decreased deep bo...
One of the targets of antiretroviral therapy is within cells infected with HIV. In order to improve therapeutic efficacy, it is therefore important that the intracellular pharmacokinetics of drugs, such as nelfinavir mesylate and its active metabolite M8, are studied in addition to plasma pharmacokinetics. Previously, the intracellular accumulation of protease inhibitors has been reported in vi...
A monoclonal antibody (MoAb), Ki-M8, that reacts specifically with cells of the monocyte/macrophage system is described. On light and electron microscopic immunohistochemistry, Ki-M8 recognizes intracytoplasmatically localized antigens of mol wt 30,000 and 32,000, increasingly expressed during differentiation of monocytes into macrophages. Ki-M8 antigen is detectable on almost all known tissue ...
3,3',4,4',5,5'-Hexahydroxy-trans-stilbene (M8) is a synthetic resveratrol derivative, advertised as a candidate drug highly effective against numerous malignancies. Because multiple tumors prone to M8 frequently metastasize into the peritoneal cavity, this study was aimed at establishing the effect of M8 on the growth and senescence of human peritoneal mesothelial cells (HPMCs), the largest cel...
The Notch effector E(spl)M8 is phosphorylated at Ser159 by CK2, a highly conserved Ser/Thr protein kinase. We have used the Gal4-UAS system to assess the role of M8 phosphorylation during bristle and eye morphogenesis by employing a non-phosphorylatable variant (M8SA) or one predicted to mimic the 'constitutively' phosphorylated protein (M8SD). We find that phosphorylation of M8 does not appear...
Microalgae have great potential to be a feedstock for producing biofuel. One of the major impediments towards the industrial-scale manufacturing of biofuel from microalgae is the ineffective separation of microalgae from water. In this communication, we first carried out froth flotation tests to harvest freshwater microalgae (Chlorella sp. BR2) and marine microalgae (Tetraselmis sp. M8) from di...
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Nelfinavir is an HIV protease inhibitor, substrate of the transporter P-glycoprotein and metabolized via CYP2C19, CYP3A4 and CYP3A5 enzymes. * Pharmacokinetic studies have shown wide interindividual variability of nelfinavir concentrations, some of this variability perhaps caused by variant drug metabolism or transporter genes. * For CYP3A4*1B and CYP3...
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