OBJECTIVE The aim of this study was to evaluate first-trimester maternal characteristics and biomarkers in pregnancies that subsequently develop HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. METHOD Maternal history, biochemical, and biophysical parameters were compared between women who developed HELLP, preeclampsia (PE) without HELLP and controls. After determination...

HELLP syndrome is a serious complication in pregnancy characterized by hemolysis, elevated liver enzymes and low platelet count [1]. First named by Weinstein in 1982, HELLP syndrome is a very serious manifestation of elevated blood pressure and proteinuria in pregnancy. Among pregnant women in the United States, approximately 5-8% will develop preeclampsia. Of those women, 15% will develop HELL...

The aim of the present study was to evaluate the histopathology in placentas from patients with severe preeclampsia with and without hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. An additional aim was to compare the prevalence of infants born small for gestational age in the 2 groups. The study is retrospective and includes 178 women who have been diagnosed at the Karol...

Both preeclampsia and the HELLP syndrome have their origin in the placenta. The aim of this study is to review genetic factors involved in development of preeclampsia and the HELLP syndrome using literature search in PubMed. A familial cohort links chromosomes 2q, 5q, and 13q to preeclampsia. The chromosome 12q is coupled with the HELLP syndrome. The STOX1 gene, the ERAP1 and 2 genes, the syncy...

OBJECTIVE Our purpose was to test the hypothesis that the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is the result of excessive vasoconstriction of the hepatic arterial circulation. STUDY DESIGN Doppler ultrasonography was used to measure the pulsatility index of the common hepatic artery in 14 women with preeclampsia, 15 with preeclampsia complicated by HELLP syndr...

Hemolysis, elevated liver enzymes and low platelet count are alterations in laboratory tests that are found in pregnant or post-delivery women who have preeclampsia. The term HELLP syndrome was coined for this set of alterations by Weinstein in 1982. Since then many reports have been presented, but the quantification of laboratory tests has differed among them. Since Sibai proposed strict crite...

ÖZET PREPARTUM VE POSTPARTUM HELLP SENDROMU : PERİPARTUM DÖNEMDE TİPİK LABORATUVAR VERİLERİN SEYRİ Amaç: Prepartum ve postpartum HELLP olgularında laboratuvar parametrelerinin değişimini incelemek. Yöntem: 1995-1998 yılları arasında izlenen 59 HELLP olgusu retrospektif olarak incelendi. Gebeler prepartum (n:37) ve postpartum (n:22) olarak iki gruba ayrıldı. Prepartum son 48 saat ile postpartum ...

RATIONALE Pravastatin has emerged for prevention and treatment of preeclampsia; no reports are available on pravastatin and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome. PATIENT CONCERNS The first pregnancy necessitated termination of pregnancy at gestational age (GA) 20+5 for HELLP. Intrauterine fetal death at GA 22+5 occurred in the second pregnancy, whilst on tempor...

The HELLP syndrome is a serious complication in pregnancy characterized by haemolysis, elevated liver enzymes and low platelet count occurring in 0.5 to 0.9% of all pregnancies and in 10–20% of cases with severe preeclampsia. Aim: The objective of the present prospective study is on incidence, diagnosis, and its variable presentations of HELLP syndrome in preeclampsia, eclampsia to analyze the ...