To gain insight into the molecular basis of cardiac repolarization, we have expressed K' channels cloned from ventricular myocardium in Xenopus oocytes. A recently identified human cardiac K' channel isoform (human Kvl.4) has properties similar to the 4-aminopyridine-sensitive calcium-insensitive component of the cardiac transient outward current. However, these channels recovered from inactiva...

To gain insight into the molecular basis of cardiac repolarization, we have expressed K' channels cloned from ventricular myocardium in Xenopus oocytes. A recently identified human cardiac K' channel isoform (human Kvl.4) has properties similar to the 4-aminopyridine-sensitive calcium-insensitive component of the cardiac transient outward current. However, these channels recovered from inactiva...

Multiple voltage-gated K' channels contribute to the repolarization phases of the cardiac action potential and are targets of several antiarrhythmic drugs. The Kvl.5 K' channel gene is expressed in the heart, and heterologous expression of this gene generates a slowly inactivating K' current. Previously, we found that glucocorticoids specifically upregulate pituitary Kvl.5 gene expression. To t...

Multiple voltage-gated K' channels contribute to the repolarization phases of the cardiac action potential and are targets of several antiarrhythmic drugs. The Kvl.5 K' channel gene is expressed in the heart, and heterologous expression of this gene generates a slowly inactivating K' current. Previously, we found that glucocorticoids specifically upregulate pituitary Kvl.5 gene expression. To t...

Synchronous differentiation of delayed-rectifier potassium curonly partially suppresses or has no effect on current. Thus, rent regulates electrical excitability and calcium entry in motor, diverse embryonic neurons coordinate differentiation of excitsensory, and interneurons of the developing amphibian spinal ability yet rely on heterogeneous potassium channel gene cord. Although Kvl and Kv2 p...

The transient outward current (ITO) is an important repolarizing component of the cardiac action potential. In native cardiac myocytes, ITO is modulated after activation of protein kinase C, although the molecular nature of this effect is not well understood. A channel recently cloned from human ventricular myocardium (KvL.4, HK1) produces a rapidly inactivating K' current, which has phenotypic...

We discuss three forms of phantom prevention locking that have been proposed in the literature: (1) predicate locking [EGLT76], (2) precision locking [JBB81], and (3) index locking (specifically, KVL/IM locking [MOHAN90, MOHAN92, MOHAN96]). The predicate locking method was dropped from consideration in System R because of perceived problems [CHETAL81]. The precision locking technique was propos...

Hyperspectral imaging with a spatial resolution of a few mm has proved to have a great potential within crop and weed classification and also within nutrient diagnostics. A commonly used hyperspectral imaging system is based on the Prism-Grating-Prism (PGP) principles produced by Specim Ltd. Finland. One of the novel systems based on the PGP spectrograph (VTTVIS) was build by The Department of ...