Solute carrier (SLC) transporters regulate the cellular influx and disposition of endogenous and xenobiotic compounds, including anticancer agents such as the multikinase inhibitors (MKIs). Recent evidence suggests that MKIs may also inhibit SLC-dependent transport of coadministered drugs, although present information on the relative susceptibilities of multiple SLC transporters is limited. Thi...

Paul Eugen Bleuler studied autism and schizophrenia, among other psychiatric disorders, throughout continental Europe in the early twentieth century. Bleuler worked as a psychiatrist caring for patients with psychiatric disorders at a variety of facilities in Europe. In 1908, Bleuler coined the term schizophrenia to describe a group of diseases that cause changes in thought processes and behavi...

, 1857 (2005); 309 Science et al. Shannon L. Werner Temporal Control of IKK Activity Stimulus Specificity of Gene Expression Programs Determined by This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtaine...

Human erythroid alpha-spectrin alleles responsible for hereditary elliptocytosis (alphaHE alleles) undergo increased incorporation into red blood cell membranes when the polymorphism alphaLELY (LELY: Low Expression LYon) occurs in trans. The alphaLELY polymorphism is characterized by a mutation in exon 40 at codon 1857 (CTA --> GTA, Leu --> Val) and the partial (50%) skipping of exon 46, which ...

TheCXCL12/CXCR4 signaling pathway is involved in the development of numerous neuronal and non-neuronal structures. Recent work established that the atypical second CXCL12 receptor, CXCR7, is essential for the proper migration of interneuron precursors in the developing cerebral cortex. Two CXCR7-mediated functions were proposed in this process: direct modulation of β-arrestin-mediated signaling...

References l.html#ref-list-1 http://rsta.royalsocietypublishing.org/content/365/1857/2103.ful This article cites 24 articles, 1 of which can be accessed free Rapid response 1857/2103 http://rsta.royalsocietypublishing.org/letters/submit/roypta;365/ Respond to this article Email alerting service here in the box at the top right-hand corner of the article or click Receive free email alerts when n...

The moment magnitude (Mw) 7.9 Fort Tejon earthquake of 1857, with a approximately 350-kilometer-long surface rupture, was the most recent major earthquake along the south-central San Andreas Fault, California. Based on previous measurements of its surface slip distribution, rupture along the approximately 60-kilometer-long Carrizo segment was thought to control the recurrence of 1857-like earth...

[Aus dem siebenten Band der Abhandlungen der Königlichen Gesellschaft der Wissenschaften zu Göttingen. 1857.]