نتایج جستجو برای: لکه گذاری dtz

تعداد نتایج: 28516  

ژورنال: :پژوهشنامه اصلاح گیاهان زراعی 0
فاطمه شورمیج سید سیامک علوی کیا محمد مقدم واحد محمود تورچی

یکی از راهکارهای اصلاح نباتات برای افزایش محتوای روی در دانه گندم، استفاده از تنوع ژنتیکی طبیعی از نظر این ویژگی است. به منظور بررسی تنوع ژنتیکی ارقام گندم بهاره ایران از لحاظ صفات مربوط به کارآیی روی و هم­چنین رابطه­ این صفات با عملکرد و اجزاء عملکرد دو آزمایش مجزا در قالب طرح بلوک­های کامل تصادفی با سه تکرار انجام شد که یکی از آزمایش­ها فاقد محلول­پاشی روی و دیگری واجد محلول­پاشی روی بود. تجز...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2009
Xin Zhang Sara K Quinney J Christopher Gorski David R Jones Stephen D Hall

Prediction of the extent and time course of drug-drug interactions (DDIs) between the mechanism-based inhibitor diltiazem (DTZ) and the CYP3A4 substrate midazolam (MDZ) is confounded by time- and concentration-dependent clearance of the inhibitor. Semiphysiologically based pharmacokinetic (PBPK) models were developed for DTZ and MDZ with the major metabolite of DTZ, N-desmethyldiltiazem (nd-DTZ...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
D Sutton A M Butler L Nadin M Murray

The antihypertensive agent diltiazem (DTZ) impairs hepatic drug metabolism by inhibition of cytochrome P450 (CYP). The accumulation of DTZ metabolites in serum occurs during prolonged therapy and leads to decreased DTZ elimination. Thus, DTZ metabolites may contribute to CYP inhibition. This study assessed the role of human CYPs in microsomal DTZ oxidation and the capacity of DTZ metabolites to...

Journal: :Annali italiani di chirurgia 2009
Behnam Sanei Mohsen Mahmoodieh Hassan Masoudpour

BACKGROUND The aim of this study was to compare the effect of topical glycerol trinitrate ointment (GTN) with topical diltiazem hydrochloride ointment (DTZ) in the treatment of chronic anal fissure. METHOD Prospectively, 102 patients were treated randomly with either GTN ointment (0.2%) or DTZ ointment (2%) couple of times daily for 12 weeks. RESULTS Forty-five patients (88.2%) in group DTZ...

2000

The objective of this in vitro study was to investigate both the intestinal metabolism and transport of diltiazem (DTZ) and its major metabolites in rat jejunum. Metabolism experiments were performed with everted sacs, whereas sheets mounted in a symmetrical twin chamber system were used in transport studies. DTZ was rapidly desacetylated by the rat jejunum to the principle metabolite desacetyl...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
D R Jones J C Gorski M A Hamman B S Mayhew S Rider S D Hall

Diltiazem (DTZ) N-demethylation occurs by cytochrome P-450 (CYP) 3A based on the following observations: 1) a single enzyme Michaelis-Menten model of metabolite formation, 2) high correlations of DTZ N-demethylation activity to other CYP3A activities, 3) inhibition of DTZ N-demethylation activity by triacetyloleandomycin, and 4) DTZ N-demethylation activity by expressed CYP3A enzymes only. The ...

2015
Laila H. Emara Ahmed A. El-Ashmawy Nesrin F. Taha

Article history: Received on: 02/03/2015 Revised on: 12/04/2015 Accepted on: 03/05/2015 Available online: 27/07/2015 The aim of this study is to investigative the stability of poly(ethylene oxide) (PEO) matrix tablets containing diltiazem hydrochloride (DTZ) after five-year storage at room temperature. DTZ matrix tablets containing different molecular weights (MW) of PEO and electrolytes (sodiu...

Journal: :Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2009
Fazila Hashmi Faisal Ghani Siddiqui

OBJECTIVE To assess and compare the effectiveness of topical 0.2% glycerl trinitrate (GTN) and topical 2% diltiazem (DTZ), in the management of chronic anal fissure. STUDY DESIGN Comparative, descriptive study. PLACE AND DURATION OF STUDY Department of Surgery, Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad from September 2004 to August 2005. METHODOLOGY Patients wi...

Journal: :Biological & pharmaceutical bulletin 2003
Noriaki Ohnishi Mayako Kusuhara Mutsunobu Yoshioka Kazuo Kuroda Akihiro Soga Fumi Nishikawa Tomokazu Koishi Masato Nakagawa Satoshi Hori Tsuyoshi Matsumoto Masayuki Yamashita Shunsaku Ohta Koji Takara Teruyoshi Yokoyama

The effects of Ginkgo biloba leaf extract (GBE), one of the most widely used herbal dietary supplements in Japan, on the pharmacokinetics of diltiazem (DTZ), a typical probe of cytochrome P450 (CYP) 3A, were examined in rats. The simultaneous addition of GBE to small intestine and liver microsomes inhibited the formation of N-demethyl DTZ (MA), an active metabolite of DTZ produced by CYP3A, in ...

Journal: :Cumhuriyet medical journal 2023

Objective: This study aimed to assess the enhanced anticancer effect of Temozolomide (TMZ) through a synergistic combination with Diltiazem (DTZ) in neuroblastoma cell line (SH-SY5Y).
 Material and Methods: The SH-SY5Y was cultured DMEM medium. TMZ DTZ stock solutions were prepared diluted obtain different concentrations. XTT assay performed evaluate viability. Cells treated alone or for 2...

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