Small RNAs have several important biological functions1. MicroRNAs (miRNAs) and trans-acting small interfering RNAs (tasiRNAs) regulate mRNA stability and translation, and siRNAs cause post-transcriptional gene silencing of transposons, viruses and transgenes and are important in both the establishment and maintenance of cytosine DNA methylation2. Here, we study the role of the four Arabidopsis...

Drug-induced liver injury (DILI) is an important cause of drug toxicity. Inhibition of multidrug resistance protein 4 (MRP4), in addition to bile salt export pump (BSEP), might be a risk factor for the development of cholestatic DILI. Recently, we demonstrated that inhibition of MRP4, in addition to BSEP, may be a risk factor for the development of cholestatic DILI. Here, we aimed to develop co...

Human molybdenum-containing enzyme mitochondrial amidoxime reducing component (mARC), cytochrome b5 type B, and NADH cytochrome b5 reductase form an N-reductive enzyme system that is capable of reducing N-hydroxylated compounds. Genetic variations are known, but their functional relevance is unclear. Our study aimed to investigate the incidence of nonsynonymous single nucleotide polymorphisms (...

Eun Mi Lee1,y, Seung Sik Lee1,y, Bhumi Nath Tripathi, Hyun Suk Jung, Guang Ping Cao, Yuno Lee, Sudhir Singh, Sung Hyun Hong, Keun Woo Lee, Sang Yeol Lee, Jae-Young Cho and Byung Yeoup Chung* Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 29 Geumgu-gil, Jeongeup 580-185, Republic of Korea, Department of Biochemistry, College of Natural Sciences, Kangwon National...

سن گلخوار یونجه، Lygus rugulipennis Poppius (Hemiptera: Miridae)، یکی از آفات مهم یونجه در بسیاری نقاط جهان می‌باشد. زیست‌شناسی آزمایشگاهی و پراسنجه‌های جدول زندگی این آفت پنج دمای 25، 5/27، 30، 5/32 35 درجه سلسیوس، رطوبت نسبی 5 ±60 درصد دوره نوری 16 ساعت روشنایی 8 تاریکی مورد بررسی قرار گرفت. قادر به نشوونما سلسیوس نبود. طولانی‌ترین کوتاه‌ترین طول پورگی به‌ترتیب 5/27 (81/13 روز) (08/8 به‌دست آ...

The G-protein-coupled receptors of the endothelial differentiation gene (EDG) family mediate pro-angiogenic activities, such as endothelial cell proliferation, chemotaxis, and vessel morphogenesis. We synthesized and tested the effects of a 9-amino acid peptide (KRX-725), derived from the second intracellular loop of S1P3 (EDG3). KRX-725 mimics the effects of sphingosine 1-phosphate (S1P), the ...