The hoe—the sound of the word is sweet...the hoe makes everything prosper, the hoe makes everything flourish. The hoe is good barley...the hoe is brick moulds, the hoe has made people exist. It is the hoe that is the strength of young manhood. The hoe and the basket are the tools for building cities. It builds the right kind of house, it cultivates the right kind of fields. It is you, hoe, that...

We studied the role of brain kinins in the regulation of cardiovascular function. Intracerebroventricular injection of 380 pmol bradykinin increased mean blood pressure by 20 +/- 2 mm Hg (P < .01) in normotensive Wistar-Kyoto (WKY) rats. Complete inhibition of this effect was achieved with intracerebroventricular administration of the newly synthesized, long-acting B2 receptor antagonist D-Arg,...

A novel system of optical see-through augmented reality (AR) is proposed by making use of a holographic optical element (HOE) with full-color and lens-array functions. The full-color lens-array HOE provides see-through property with three-dimensional (3D) virtual images, for it functions as a conventional lens array only for Bragg-matched lights. An HOE recording setup was built, and it recorde...

OBJECTIVES We investigated whether the Na+-H+ exchange inhibitor, HOE642 (Hoe), and/or the Na channel blocker, mexiletine (Mex), enhance a cardioprotective effect on St. Thomas' Hospital cardioplegic solution (STS) to clarify the mechanism by which intracellular Na+ is accumulated after cardioplegic arrest. MATERIALS AND METHODS Isolated working rat hearts were perfused with Krebs-Henseleit b...

BACKGROUND Experiments were carried out using the new Na(+)-H+ exchange inhibitor (3-methylsulfonyl-4-piperidinobenzoyl)guanidine methanesulfonate (HOE 694) to assess the role of Na(+)-H+ exchange in myocardial ischemic and reperfusion injury. METHODS AND RESULTS Three groups of rabbit hearts (n = 5 in each) were perfused with blood and were subjected to 45 minutes of global normothermic (37 ...

Acute hypertension inhibits proximal tubule (PT) fluid reabsorption. The resultant increase in end proximal flow rate provides the error signal to mediate tubuloglomerular feedback autoregulation of renal blood flow and glomerular filtration rate and suppresses renal renin secretion. To test whether the suppression of the renin-angiotensin system during acute hypertension affects the magnitude ...

BACKGROUND The accumulation of intracellular sodium during myocardial ischemia couples an inappropriate calcium influx and depressed cardiac recovery during subsequent reperfusion. The effects of the selective sodium/ hydrogen exchange inhibitor HOE 694 are evaluated during myocardial ischemia and reperfusion. METHODS Ten isolated rat hearts were subjected to a 2-minute infusion of St. Thomas...

1. The effects of intrathecally (i.t.) injected kinin B(1) and B(2) receptor agonists and antagonists were measured on mean arterial pressure (MAP) and heart rate (HR) of conscious unrestrained spontaneously hypertensive rats (SHR of 16 weeks old) and age-matched normotensive Wistar Kyoto (WKY). Quantitative in vitro autoradiographic studies were also performed on the thoracic spinal cord of bo...

A new insect growth regulator, Hoe 522 (CME-134), was tested in the field in the northern Philippines for the control of diamondback moth, Plutella xylostella L which had developed resistance to a large number of insecticides. Hoe 522 was found to be highly effective against diamondback moth populations at all rates from 15 to 105 g Al/ha and performed significantly better than reference produc...