In the present study, we have investigated the mechanism of affinity modulation of mll& by chymotrypsin. We first confirmed that mu-chymotrypsin could activate a143 (-7,000 molecules per platelet) without major intracellular signaling. However, we unexpectedly found that high concentrations of amiloride dose-dependently inhibited '%fibrinogen binding to the chymotrypsin-treated platelets, as we...

Apple scab caused by Venturia inaequalis (Cke.) Wint. is the most important disease of apple trees worldwide and requires a high number fungicide applications. The G143A substitution in inhibitor binding site cytochrome b V. confers level resistance to strobilurins targeting bc1 complex. aim this work was substitute labor intensive vitro assays, with faster quantitative PCR. An allele-specific ...