نتایج جستجو برای: پارامتر U/Uc

تعداد نتایج: 15341  

2016
Yehong Han Dawei Shou Liang Wen Jianguang Shi Jian Ding Ping Gong Weihua Gong

Although upper tract urothelial carcinomas (UUC) is curable through nephrectomy or nephroureterectomy, progression of chronic kidney disease (CKD) and CKD-related mortality have been highlighted as clinical challenges in recent years owing to the loss of a large number of nephrons. While CKD can promote the development of UUC, other risk factors such as hypertension, diabetes mellitus, advanced...

2009
Ljubinka Jankovic Velickovic Takanori Hattori Vladisav Stefanovic

The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper urothelial carcinoma (UUC) was recently confirmed. The aim of this study was to determine the marker(s) specific for BEN-associated UUC. A total of 82 patients with UUC (38 from the BEN region and 44 control tumors) were included in the study. The Ki-67 index in BEN tumors correlated with the ...

2015
LE TAO YIGANG ZENG JUN WANG ZHIHONG LIU BING SHEN JIFU GE YONG LIU YIFENG GUO JIANXIN QIU

Aristolochic acid (AA) is a carcinogenic, mutagenic and nephrotoxic compound commonly isolated from members of the plant family of Aristolochiaceae (such as Aristolochia and Asarum) and used in Chinese herbal medicine. Use of AA and AA‑containing plants causes chronic kidney disease (CKD) and upper urinary tract carcinoma (UUC); however, the underlying mechanism remains to be defined. miRNAs re...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001
V Petronić M Savin

The upper urothelial carcinomas (UUC) associated with endemic nephropathy and analgesic nephropathy are considerably similar in many characteristics. These similarities diversify them from the same carcinomas in the general population w1x. Bilateral occurrence (simultaneous or successive) of the UUC is observed in about 8% cases of analgesic nephropathy and 10–14% in endemic Balkan nephropathy....

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Chung-Hsin Chen Kathleen G Dickman Masaaki Moriya Jiri Zavadil Viktoriya S Sidorenko Karen L Edwards Dmitri V Gnatenko Lin Wu Robert J Turesky Xue-Ru Wu Yeong-Shiau Pu Arthur P Grollman

Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated with urothelial carcinoma of the upper urinary tract (UUC). Following metabolic activation, aristolochic acid reacts with DNA to form aristolactam (AL)-DNA adducts. These lesions concentrate in the renal cortex, where they serve as a sensitive and specific biomarker of exposure, and are found also in the...

2017
Marie Stiborová Volker M Arlt Heinz H Schmeiser

Aristolochic acid (AA) is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases frequently associated with upper urothelial cancer (UUC). This review summarizes the significance of AA-derived DNA adducts in the aetiology of UUC leading to specific A:T to T:A transversion mutations (mutational signature) in AAN/BEN-associated...

Journal: :Vojnosanitetski pregled 2011
Zana Dolićanin Ljubinka Janković Velicković Biljana Djordjević Milan Visnjić Ivana Pesić Ana Ristić Vesna Marjanović

BACKGROUND/AIM Deregulation of the normal cell cycle is common in upper urothelial carcinoma (UUC). The aim of this study was to investigate the expression of regulatory proteins of the cell cycle (p53, p16, cyclin D1, HER-2) and proliferative Ki-67 activity in UUC, and to determine their interaction and influence on the phenotypic characteristics of UUC. METHODS In 44 patients with UUC, hist...

Journal: :Molecular phylogenetics and evolution 2005
Randall L Small Edgar B Lickey Joey Shaw Warren D Hauk

Noncoding DNA sequences from numerous regions of the chloroplast genome have provided a significant source of characters for phylogenetic studies in seed plants. In lycophytes and monilophytes (leptosporangiate ferns, eusporangiate ferns, Psilotaceae, and Equisetaceae), on the other hand, relatively few noncoding chloroplast DNA regions have been explored. We screened 30 lycophyte and monilophy...

2002
Vladimir Petronic Marina Savin

The incidence of upper urothelial carcinomas (UUC) is even more than hundred times higher in the foci of Balkan endemic nephropathy (BEN), by investigations of our team, and others. Every tenth patient suffers from both diseases. Etiology is unknown. It would seem that BEN is a tubulointerstitial nephritis associated with urothelial malignancy. We found that apoptosis plays an important role in...

Journal: :Kidney & blood pressure research 2013
Sandra Karanović Ivana Vuković Lela Bojan Jelaković Kathleen G Dickman Anamarija Kovač Peić Damir Dittrich Matej Knežević Vesna Matijević Andrea S Fernandes Frederick Miller

BACKGROUND Endemic nephropathy (EN) and associated urothelial cell cancers (UUC) are an environmental form of aristolochic acid nephropathy where the most probable rout of ingestion of aristolochic acid (AA) was made by bread contaminated with AA, leading to chronic dietary intoxication. Clinical courses of three members of the same family, similarly exposed to toxin, who exhibited different cl...

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