The receptors for human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 are composed of a ligand-specific alpha-chain (eg, alpha-GM-CSF receptor [alpha-GMR]) and a common beta-subunit (beta-GMR). Ligand binding is believed to induce assembly or conformational changes in preformed complexes containing more than one alpha- and beta-subunit in the activate...

To determine the expression and function of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha chain (GMR alpha) during hematopoiesis and on leukemic cells, monoclonal antibodies were raised by immunizing mice with cells expressing high levels of human GMR alpha. A pool of five antibodies isolated from three different mice was used to characterize GMR alpha. This antib...

This paper addresses the problem of the adaptation of a Gaussian Mixture Regression (GMR) to a new input distribution, using a limited amount of input-only examples. We propose a new model for GMR adaptation, called Joint GMR (J-GMR), that extends the previously published framework of Cascaded GMR (C-GMR). We provide an exact EM training algorithm for the J-GMR. We discuss the merits of the J-G...

OBJECTIVES To investigate the spectrum of growth rates in melanomas and to identify clinical associations of rapidly growing melanomas. DESIGN Clinical interview, skin examination, and pathology review. SETTING Three tertiary melanoma referral centers and 2 private dermatology practices. PATIENTS A total of 404 consecutive patients with invasive primary cutaneous melanomas. MAIN OUTCOME...

The GMR editorial staff was alerted about some manuscripts that were found to be substantially equal. The Publisher and Editor decided to retract these articles in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation, we have strong reason to believe that the peer review process was failure and, after review and contacting the authors...

The genetic determinant encoding gentamicin resistance (Gmr) on the beta-lactamase encoding plasmid pBEM10 of Enterococcus faecalis HH22 is carried on a transposon, termed Tn5281, that is highly related to the staphylococcal Gmr transposons Tn4001 found in Australian isolates of Staphylococcus aureus and Tn4031 found in United States isolates of Staphylococcus epidermidis. We have now studied p...

Giant magnetoresistive (GMR) biosensors have emerged as powerful tools for ultrasensitive, multiplexed, real-time electrical readout, and rapid biological/chemical detection while combining with magnetic particles. Finding appropriate magnetic nanoparticles (MNPs) and its influences on the detection signal is a vital aspect to the GMR bio-sensing technology. Here, we report a GMR sensor based d...

We present a numerical and experimental study of a guided-mode-resonance (GMR) device for detecting surface-bound light-absorbing thin films. The GMR device functions as an optical resonator at the wavelength strongly absorbed by the thin film. The GMR mode produces an evanescent field that results in enhanced optical absorption by the thin film. For a 100-nm-thick lossy thin film, the GMR devi...

With the extensive applications of biomagnetic signals derived from active biological tissue in both clinical diagnoses and human-computer-interaction, there is an increasing need for approachable weak biomagnetic sensing technology. The inherent merits of giant magnetoresistance (GMR) and its high integration with multiple technologies makes it possible to detect weak biomagnetic signals with ...