Background: Warfarin is a common anticoagulant drug that has a narrow therapeutic index; higher dose causes excessive bleeding and lower dose leads to cerebrovascular clotting and stroke in patients. Genetic factors that have been associated with warfarin response are the genes of cytochrome P450 2C9 (CYP2C9), which metabolize the more active S-enantiomer of warfarin, and vitamin K epoxide redu...

background: warfarin is a common anticoagulant drug that has a narrow therapeutic index; higher dose causes excessive bleeding and lower dose leads to cerebrovascular clotting and stroke in patients. genetic factors that have been associated with warfarin response are the genes of cytochrome p450 2c9 (cyp2c9), which metabolize the more active s-enantiomer of warfarin, and vitamin k epoxide redu...

Abstract Background This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 phenytoin-induced dose-related toxicity assess if presence allele CYP2C9*3 plays a role idiosyncratic adverse effects. Current observational case control included 142 patients with drug reactions (ADRs) 100 controls. All these underwent genotyping determine type [CYP2C9...

conclusions simpleprobe® real-time pcr is a fast and accurate technique qualified to detect vkorc1 and cyp2c9 snps. these results encourage taking further steps towards using vkorc1 and cyp2c9 allelic screening to prevent clinical complications due to resistance or sensitivity to warfarin as well as anti-coagulant dose adjustment. results the allelic frequencies for vkorc1 c1173t (cc, ct, tt) w...

Abstract Saliva is widely used for clinical and laboratory analysis. This study proposed to use DNA extracted from saliva genotyping pharmacokinetics of piroxicam. A fast efficient method was determine relevant allelic variants CYP2C9 (*2 *3), since genetic factors can influence in non-steroidal anti-inflammatory drugs (NSAIDs) metabolization. Extract All Reagents Kit® extraction performed usin...

allele frequencies of single nucleotide polymorphisms (snps) are variable among different populations; therefore the study of snps in ethnic groups is important for establishing the clinical significance of the screening of these polymorphisms. the main goal of the research is to study the polymorphisms of cyp2c9 , cyp2c19 , vkorc1 , and slco1b1 in yakuts. genomic dna from 229 yakut subjects we...