Growth hormone-activated STAT5b is an essential regulator of sex-differential gene expression in mouse liver; however, its impact on hepatic and epigenetic responses poorly understood. Here, we found a substantial, albeit incomplete loss liver sex bias hepatocyte-specific STAT5a/STAT5b (collectively, STAT5)-deficient liver. In male liver, many male-biased genes were downregulated direct associa...

Abstract Background and Aims During glomerular diseases, podocyte-specific pathways can modulate the intensity of histological disease prognosis. The therapeutic targeting these could thus improve management prognosis kidney diseases. Janus Kinase/ Signal Transducer Activator Transcription (JAK/STAT) pathway, classically described in immune cells, has been recently detailed intrinsic cells. We ...

Electroacupuncture (EA) can help reduce infarct size and injury resulting from myocardial ischemia/reperfusion (I/R); however, the underlying molecular mechanism remains unknown. We previously reported that STAT5 plays a critical role in cardioprotective effect of remote ischemic preconditioning (RIPC). Here, we assessed effects electroacupuncture pretreatment (EAP) on I/R presence and/or absen...

Signal Transducers and Activators of Transcription (STATs) are key components of the JAK/STAT pathway. Of the seven STATs, STAT5A and STAT5B are of particular interest for their critical roles in cellular differentiation, adipogenesis, oncogenesis, and immune function. The interactions of STAT5A and STAT5B with cytokine/hormone receptors, nuclear receptors, transcriptional regulators, proto-onc...

Signal transducer and activator of transcription (Stat)5 has been implicated in the signal transduction pathways of several factors that are lactogenic or galactopoeitic in mammary cells, including prolactin, GH, and IGF-I. Data from cell or explant culture support the concept that Stat5 may represent part of a common route by which different extracellular signals converge and are transduced in...

STAT5 is a transcription factor essential for hematopoietic physiology. STAT5 functions to transduce signals from cytokines to the nucleus where it regulates gene expression. Although several important transcriptional targets of STAT5 are known, most remain unidentified. To identify novel STAT5 targets, we searched chromosomes 21 and 22 for clusters of STAT5 binding sites contained within regio...

Signal transducer and activator of transcription 5 (STAT5) and nucleophosmin (NPM1) are critical regulators of multiple biological and pathological processes. Although a reciprocal regulatory relationship was established between STAT5A and a NPM-ALK fusion protein in T-cell lymphoma, no direct connection between STAT5 and wild-type NPM1 has been documented. Here we demonstrate a mutually regula...

GM-CSF signals through JAK2 and STAT5 and stimulates the expression of STAT5 target genes, such as pim-1 and CIS. Analyzed by EMSA, GM-CSF stimulation led to much stronger STAT5 DNA-binding to pim-1 or CIS GAS elements in primary human monocytes compared with mature macrophages. Similarly, GM-CSF-induced expression of pim-1 and CIS mRNAs was much stronger in monocytes. These differencies were n...