نتایج جستجو برای: ژن tnfrsf6b
تعداد نتایج: 15848 فیلتر نتایج به سال:
پیش زمینه و هدف: بیماری مالتیپل اسکلروزیس یک بیماری خودایمن، دمیلینه کننده و تخریب کننده سیستم اعصاب مرکزی است. آسیب شناسی این بیماری تاکنون مشخص نشده است، اگرچه شواهدی حاکی از تأثیر عوامل محیطی بر افراد دارای استعداد ژنتیکی وجود دارد. پروتئین tnfrsf6b در انسان توسط ژن tnfrsf6b تولید می گردد. یکی از عملکردهای بیولوژیکی tnfrsf6b، عمل کردن به عنوان تله مرگ و جلوگیری از مرگ سلولی تحت شرایط خاص است...
Background & Aims: Multiple Sclerosis (MS) is an autoimmune, demyelinating and neurodegenerative disease of the central nervous system (CNS). The pathogenesis of this disease is still unknown, although there are evidences of environmental factors affecting subjects with genetic predisposition factors. TNFRSF6B protein in human is coded by the tnfrsf6b gene. One of the biological functi...
Familial clustering and genome-wide linkage scans strongly support a genetic susceptibility to familial IgA nephropathy (IgAN), but genetic factors that predispose to sporadic IgAN are unknown. A high-throughput single nucleotide polymorphism (SNP) association study was conducted using a customized Illumina BeadChip in 732 white patients with biopsy-proven IgAN and 503 control subjects from Can...
DNA sequence is located on chromosome 20. Transcription consists of 7 exons and 6 introns, spanning 3.6kb. A shorter transcription variance (M68E) has been identified, and is transcribed from 3 exons and 2 introns spanning 1.9kb as illustrated above. The difference occurs at the 5' untranslated region, but the two transcripts encode the same isoform. Mice do not have a gene orthologue to human ...
Genetic susceptibility is an important contributor to the pathogenesis of Crohn's disease (CD). We investigated multiple CD susceptibility genes in an Australian paediatric onset CD cohort. Newly diagnosed paediatric onset CD patients (n = 72) and controls (n = 98) were genotyped for 34 single nucleotide polymorphisms (SNPs) in 18 genetic loci. Gene-gene interaction analysis, gene-disease pheno...
Genetic effects play a role in hand eczema (HE), according to population-based twin and candidate gene studies. However, the genetic factors responsible for HE are not fully understood. Therefore, aim of this study was identify characterize loci associated with Lifelines, Dutch general prospective cohort biobank study. The primary analysis consisted 2.789 cases self-reported 12.316 healthy cont...
Early diagnosis of sepsis is critical for successful treatment. The clinical value of DcR3 in early diagnosis of sepsis was determined in a dynamic follow-up study. Alterations in plasma levels of DcR3, PCT, CRP, and IL-6 were measured by ELISA and compared among patients with sepsis (n = 134), SIRS (n = 60) and normal adults (n = 50). Correlations and dynamic patterns among the biomarkers, APA...
Islet primary nonfunction (PNF) is defined as the loss of islet function after transplantation for reasons other than graft rejection. It is a major obstacle to successful and efficient islet transplantation. DcR3/TR6 is a soluble death decoy receptor belonging to the tumor necrosis factor (TNF) receptor family, and it can block apoptosis mediated by several TNF receptor family members such as ...
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