Previous drug selection experiments resulted in the isolation of a human cytomegalovirus (CMV) UL97 phosphotransferase mutant resistant to the benzimidazole compound maribavir (1263W94), reflecting the anti-UL97 effect of this drug. Three other CMV strains were plaque purified during these experiments. These strains showed lower-grade resistance to maribavir than the UL97 mutant. Extensive DNA ...

1-(beta-D-Ribofuranosyl)-2,5,6-trichlorobenzimidazole (TCRB) and its 2-bromo analog, BDCRB, are potent and selective inhibitors of human cytomegalovirus (HCMV) DNA processing and packaging. Since they are readily metabolized in vivo, analogs were synthesized to improve biostability. One of these, 1-(beta-L-ribofuranosyl)-2-isopropylamino-5,6-dichlorobenzimidazole (1263W94; maribavir), inhibits ...

Background and Aims: Human Cytomegalovirus (HCMV) is one of the life-threatening agents in immunosuppressed patients and congenitally infected neonates in the world. Mutations in UL27 were suggested to confer low- to high-grade Maribavir (MBV) resistance. As pUL27 R233S variation may involve in either MBV-resistance, we aimed to establish a method for identifying R233 coding sequence mutation...

| Bovine herpesvirus-1 (BHV-1) causes infectious bovine rhinotracheitis (IBR) and infectious pustular vulvovaginitis / balanoposthitis (IPV/IPB) in cattle and buffaloes. BHV-1 is closely related to bovine herpesvirus-5 (BHV-5), which has been recovered from both genital and respiratory tracts of cattle and buffaloes. Perusal of literature reveals paucity of information on genetic characteristic...

Objective: Monkey B virus (BV) infection in humans and other macaque species has a mortality rate of approximately 80%. Because BV infects through bites, scratches, injuries inflicted by macaques, the simple rapid diagnosis field laboratories is great importance to protect veterinarians, laboratory researchers, support personnels from threat infection. Methods: Two recombinase polymerase amplif...