The COBRA protein is found only in higher plants and algae, and has been implicated in cellulose synthesis, but its specific function remains unknown. To shed light on COBRA function we tested the ability of putative Arabidopsis COBRA orthologs to complement mutations in the COBRA gene. We expanded the previously published phylogenetic analysis and found that COBRA genes can be grouped into fiv...

Résumé : Cet article présente un projet en cours qui a pour objectif de développer une plateforme de RàPC pour le diagnostic basée sur des ontologies, appelée COBRA. Cette plate-forme est constituée de deux parties principales : les modèles de connaissances décrits par des ontologies, et les processus de raisonnement. Nous travaillons actuellement sur la défaillance des barrières de sécurité in...

BACKGROUND Early, intensive treatment of rheumatoid arthritis (RA) with the combination of (initially high dose) prednisolone, methotrexate and sulfasalazine (COBRA therapy) considerably lowers disease activity and suppresses radiological progression, but is infrequently prescribed in daily practice. Attenuating the COBRA regimen might lessen concerns about side effects, but the efficacy of suc...

Aunque la sostenibilidad del sistema siempre ha estado presente en los escenarios de debate de la política sanitaria, qué duda cabe de que la crisis financiera de finales de la primera década del siglo xxi y principios de la segunda ha añadido intensidad y polarización a la discusión. La crisis ha añadido evidentes artefactos exógenos a las cuestiones endógenas relativas a la preocupación por l...

Cobra neurotoxin, a short-chain peptide isolated from snake venom of Naja naja atra, showed both a central analgesic effect and a hyperalgesic effect in mice tests. In order to explore mechanisms, a hypothesis is put forward that cobra neurotoxin takes effect through adenosine receptor pathway. The central effects of cobra neurotoxin were evaluated using the hot plate test (a model of acute pai...

BACKGROUND Recently, we documented the likely non-inferiority of Combinatietherapie Bij Reumatoïde Artritis (COBRA)-light therapy (methotrexate increased to 25 mg/week with initial prednisolone 30 mg/day) compared with the original COBRA therapy (methotrexate 7.5 mg/week, sulfasalazine 2 g/day, with initial prednisolone 60 mg/day) after 26 weeks in patients with early active rheumatoid arthriti...