Malformations of cortical development (MCDs) result from a disruption in the process human brain cortex formation: currently, there are no pharmacological treatments for diffuse MCDs. Next-generation sequencing has accelerated identification MCDs causing genes: some cases, functional studies needed to clarify role genetic variants. The aim this PhD project been apply multidisciplinary approach ...

In wireless sensor network, a connected dominating set (CDS) can be used as a virtual backbone for efficient routing. Constructing a minimal CDS (MCDS) is good for packet routing and energy efficiency, but is an NP-hard problem. In this article, an efficient approximation MCDS construction algorithm E-MCDS (energy efficient MCDS construction algorithm) is proposed which explicitly takes energy ...

Nodes of minimum connected dominating set (MCDS) form a virtual backbone in a wireless adhoc network. In this paper, a modified approach is presented to determine MCDS of an underlying graph of a Wireless Adhoc network. Simulation results for a variety of graphs indicate that the approach is efficient in determining the MCDS as compared to other existing techniques.

Malformations of cortical development (MCDs) are increasingly being recognized as a common cause of epilepsy in cases previously felt to be cryptogenic. MCDs occur when the normal process of cerebral cortical development is disrupted, and include disorders of neuronal proliferation, migration, and organization. Many have a genetic basis and the genes responsible for some MCDs have been identifi...

Connected Dominating Set (CDS) problem in unit disk graph has a significant impact on an efficient design of routing protocols in wireless sensor networks. In this paper, an algorithm is proposed for finding Minimum Connected Dominating Set (MCDS) using Dominating Set. Dominating Sets are connected by using Steiner tree. The algorithm goes through three phases. In first phase Dominating Sets ar...

Schmid metaphyseal chondrodysplasia (MCDS) involves dwarfism and growth plate cartilage hypertrophic zone expansion resulting from dominant mutations in the hypertrophic zone collagen, Col10a1. Mouse models phenocopying MCDS through the expression of an exogenous misfolding protein in the endoplasmic reticulum (ER) in hypertrophic chondrocytes have demonstrated the central importance of ER stre...

We present a detailed simulation based performance study of our recently proposed strong-neighborhood based connected dominating sets (SN-CDS) for mobile ad hoc networks (MANETs). We compare the performance of SN-CDS with that of the well-known minimum connected dominating sets (MCDS) and the ID-based connected dominating sets (ID-CDS) for MANETs. We show that by computing the SN-CDS involving ...

Type X collagen is a homotrimer of alpha 1 (X) chains encoded by the COL10A1 gene. It is synthesised specifically and transiently by hypertrophic chondrocytes at sites of endochondral ossification. Point mutations and deletions in the region of the COL10A1 gene encoding the alpha 1 (X) carboxyl-terminal (NC1) domain have previously been identified in subjects with metaphyseal chondrodysplasia t...

PURPOSE Malformations of cortical development (MCDs) are abnormalities of the cerebral cortex that arise from abnormal formation of the cortical plate, and have become increasingly identified as an important etiology for refractory epilepsy. Little is known about the spectrum, distribution and clinical features of MCDs, especially in resource-limited regions. This study investigates the distrib...

Communication protocols for mobile ad hoc networks (MANETs) follow either an Optimum Routing Approach (ORA) or the Least Overhead Routing Approach (LORA): With ORA, protocols tend to determine and use the optimal communication structure at every time instant; whereas with LORA, a protocol tends to use a chosen communication structure as long as it exists. In this paper, we study the impact of t...