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Phosphorothioate has proven to be a useful skeleton in organic synthesis as a valuable building block, in pharmaceuticals and pesticides due to its biological and physical properties. In particular, S-aryl phosphorothioate represents an important structural element in antiproliferative agents (A), pesticides (B), antibacterials (C), curing accelerators (D), antistatic agents (E), and anticholin...
Simulating solid propellant rocket motors requires solving an extremely complex, fully coupled multidisciplinary physics problem that spans a wide range of length and time scales. We have taken a staged approach in developing an integrated whole-system rocket simulation package, beginning with relatively simple physical models, geometries, and coupling in our first-generation code (GEN1), and p...
This study aims to provide the means for testicular dose estimation from radiotherapy for rectal cancer. Rectal irradiation was simulated on a humanoid phantom using a 6 MV photon beam. The effect of field size, distance from irradiated area, wedge introduction into lateral beams, tissue thickness along the beam axis and use of gonad shields on the testicular dose was examined. Testicular dose ...
In the mol-ecule of the title compound, C(6)H(8)N(2), the methyl C and amine N atoms are 0.021 (2) and 0.058 (2) Å from the pyridine ring plane. In the crystal structure, inter-molecular N-H⋯N hydrogen bonds link the mol-ecules.
Cisplatin is a DNA-damaging chemotherapeutic drug that may have a role in the adjuvant chemotherapy of several solid tumors, such as malignant glioblastoma, and the status of p53 tumor suppressor protein is a critical determinant of cisplatin chemosensitivity. In the present study, we showed the relationship of p53 status and chemosensitivity of cisplatin between two human malignant glioblastom...
Single crystals of tetracalcium iridium hexaoxide, Ca(4)IrO(6), tricalcium magnesium iridium hexaoxide, Ca(3)MgIrO(6), and tricalcium zinc iridium hexaoxide, Ca(3)ZnIrO(6), were prepared via high-temperature flux growth and structurally characterized by single-crystal X-ray diffraction. The three compounds are isostructural and adopt the K(4)CdCl(6) structure type, comprised of chains of altern...
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