نتایج جستجو برای: cu2

تعداد نتایج: 3746  

2014
Wenyue Yu Lin-Hua Jiang Yang Zheng Xupang Hu Jianhong Luo Wei Yang

Cu2+ is an essential metal ion that plays a critical role in the regulation of a number of ion channels and receptors in addition to acting as a cofactor in a variety of enzymes. Here, we showed that human melastatin transient receptor potential 2 (hTRPM2) channel is sensitive to inhibition by extracellular Cu2+. Cu2+ at concentrations as low as 3 µM inhibited the hTRPM2 channel completely and ...

Journal: :Journal of nutritional science and vitaminology 1983
K Shinohara M So M Nonaka K Nishiyama H Murakami H Omura

The role of Cu2+ on the DNA-breaking action of ascorbic acid (AsA) and triose reductone (TR) was studied with an agarose slab gel electrophoretic analysis. AsA and TR decomposed calf thymus DNA which had been pretreated with Cu2+, and their decomposing activity was proportional to the concentration of Cu2+ bound to the DNA. The DNA-Cu2+ complex had the ability to oxidize reductones. AsA and TR ...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2007
Hiroyasu Ito Masahiro Inouhe Hiroshi Tohoyama Masanori Joho

Acid phosphatase (APase) activity of the yeast Yarrowia lipolytica increased with increasing Cu2+ concentrations in the medium. Furthermore, the enzyme in soluble form was stimulated in vitro by Cu2+, Co2+, Ni2+, Mn2+ and Mg2+ and inhibited by Ag+ and Cd2+. The most effective ion was Cu2+, especially for the enzyme from cultures in medium containing Cu2+, whereas APase activity in wall-bound fr...

Journal: :Plant physiology 2004
Richard Shingles Larry E Wimmers Richard E McCarty

The initial rate of Cu2+ movement across the thylakoid membrane of pea (Pisum sativum) chloroplasts was directly measured by stopped-flow spectrofluorometry using membranes loaded with the Cu(2+)-sensitive fluorophore Phen Green SK. Cu2+ transport was rapid, reaching completion within 0.5 s. The initial rate of uptake was dependent upon Cu2+ concentration and saturated at about 0.6 microm total...

Journal: :Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2002
Tamio Kamidate Yasunori Hashimoto Hirofumi Tani Akihiko Ishida

The uptake of Cu2+ was investigated using various types of liposomes composed of phosphatidylcholine (PC), cholesterol (Chol) and dicethylphosphate (DCP). DCP played a role as a ligand for Cu2+. Multilamellar vesicles (MLVs) were more effective for the uptake of Cu2+ compared to unilamellar vesicles prepared by the extrusion technique. The uptake efficiency of MLVs for Cu2+ was dependent on the...

Journal: :Angewandte Chemie 2014
Qing Hua Tian Cao Xiang-Kui Gu Jiqing Lu Zhiquan Jiang Xiaorong Pan Liangfeng Luo Wei-Xue Li Weixin Huang

The selective oxidation of propylene with O2 to propylene oxide and acrolein is of great interest and importance. We report the crystal-plane-controlled selectivity of uniform capping-ligand-free Cu2 O octahedra, cubes, and rhombic dodecahedra in catalyzing propylene oxidation with O2 : Cu2 O octahedra exposing {111} crystal planes are most selective for acrolein; Cu2 O cubes exposing {100} cry...

Journal: :Environment international 2001
H P He J G Guo X D Xie J L Peng

Locations of Cu2+ ion in Cu(2+)-adsorbed montmorillonite have been studied by electron paramagnetic resonance (EPR), supplemented by X-ray diffraction (XRD) and differential thermal analysis (DTA). In the EPR spectra of Cu(2+)-adsorbed montmorillonite, three signals, corresponding to Cu2+ ion, have been simultaneously recorded. Some Cu2+ ions seemed to replace the original interlayer metal cati...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004
Waldo F Cerpa María I Barría Marcelo A Chacón Miriam Suazo Mauricio González Carlos Opazo Ashley I Bush Nibaldo C Inestrosa

The amyloid precursor protein (APP) contains a Cu binding domain (CuBD) localized between amino acids 135 and 156 (APP135-156), which can reduce Cu2+ to Cu1+ in vitro. The physiological function of this APP domain has not yet being established; nevertheless several studies support the notion that the CuBD of APP is involved in Cu homeostasis. We used APP synthetic peptides to evaluate their pro...

Journal: :Toxicology letters 1996
J Li R A Lock P H Klaren H G Swarts F M Schuurmans Stekhoven S E Wendelaar Bonga G Flik

The interaction of Cu2+ with enzymatic activity of rabbit kidney Na+/K(+)-ATPase was studied in media with buffered, defined free Cu2+ levels. The IC50-values are 0.1 mumol/l for Na+/K(+)-ATPase and 1 mumol/l for K(+)-pNPPase. Dithiothreitol (DTT) reverses the inhibitory effect of Cu2+ in vitro. Cu2+ exerts non-competitive effects on the enzyme with respect to Na+, K+, ATP or pNPP, but has a mi...

2017
Lucas C Wheeler Michael J Harms

Background S100A5 is a calcium binding protein found in a small subset of amniote tissues. Little is known about the biological roles of S100A5, but it may be involved in inflammation and olfactory signaling. Previous work indicated that S100A5 displays antagonism between binding of Ca2+ and Cu2+ ions-one of the most commonly cited features of the protein. We set out to characterize the interpl...

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