نتایج جستجو برای: .erbb2
تعداد نتایج: 9064 فیلتر نتایج به سال:
سرطان پستان شایع¬ترین و مهم ترین بدخیمی در بین زنان در سراسر دنیا است. سلول¬های سرطانی از مسیرهای سیگنالینگ مختلف و متعدد گیرنده¬های خانواده فاکتور رشد اپیدرمال، جهت مقاومت به آنتی¬بادی-های ضد سرطانی مثل trastuzumab بهره می برند. مسیرهای سیگنالینگ همپوشان گیرنده های erbb1 و erbb2 از مهم ترین علل شکست استراتژی های درمانی در سرطان پستان می باشد. هدف از این مطالعه تولید آنتی بادی های نوترکیب انسان...
background: genes for human epidermal growth factor receptors b1 (erbb1) and b2 (erbb2) were amplified in breast and ovarian cancers. both of them were associated with aggressive disease and worse prognosis. the erbb1 or erbb2 status of a tumor may provide an indication of the response to erbb1 and erbb2 -targeted therapies. for accurate and rapid assessment of amplification of erbb1 and erbb2 ...
background although neuregulin-1 （nrg1）and its receptors have been indicated at the mrna level in partial human endocrine organs and its functional roles have been evaluated in vitro, their morphological distribution in higher animals are not fully studied. the present research focused on expression of nrg1 and its main receptors erbb2 and erbb4 in main endocrine organs of the rhesus monkey. ma...
Background: Status of tumor receptor, including estrogen receptor(ER), progesterone receptor(PR) and Erb-B2 Receptor Tyrosine Kinase 2(ERBB2), is important to predict clinical behavior in breast cancer. Cutaneous metastasis from cancer a dismal sign. However, whether the receptor status would differ primary skin metastatic sites conversion affect remain unknown. Methods: From 2002 2021, 41 pati...
Analysis of a collection of human breast cancers (n = 150), enriched in ERBB2-positive cases (n = 57) and involving tumor genotyping relative to population-matched blood genotyping (n = 749) for a common ERBB2 single nucleotide polymorphism Ala(G)1170Pro(C), revealed that ERBB2 amplification in breast cancer is invariably monoallelic. Analysis of paired breast cancer and blood samples from info...
erbB2 gene plays an important role in carcinoma formation. erbB2 overexpression was observed in many types of tumours, including salivary carcinoma. However, a putative erbB2 and PTEN interaction remains largely unknown in salivary adenoid cystic carcinoma cells. The purpose of this study was to silence erbB2 gene and investigate the functional relationship between erbB2 and PTEN in SACC-83 sal...
UNLABELLED Breast cancer displays significant intratumoral heterogeneity, which has been shown to have a substantial impact on both innate and acquired resistance to tyrosine kinase inhibitors. The heterogeneous expression of multiple receptor tyrosine kinases (RTK) in cancers supports tumor signaling robustness and plays a significant role in resistance to targeted inhibition. Recent studies h...
ErbB2 tyrosine kinase inhibitors (TKI) block tyrosine autophosphorylation and activation of the full-length transmembrane ErbB2 receptor (p185(ErbB2)). In addition to p185(ErbB2), truncated forms of ErbB2 exist in breast cancer cell lines and clinical tumors. The contribution of these truncated forms, specifically those expressed in tumor cell nuclei, to the development of therapeutic resistanc...
Introduction: Breast cancer is the most common cancer and the first cause of cancer-related death in women worldwide. Although admirable achievements have been made in finding new therapeutic interventions, introducing efficient approaches with the least side effect is still undoubtedly demanded. Exposure to extremely-low frequency electromagnetic field (ELF-EMF) with specific parameters of fre...
Overexpression of ErbB2 and ErbB3 is found in several human cancers, and ErbB2-ErbB3 heterodimers are known as the most potent signaling units among ErbB dimers. While ErbB2 probably undergoes weak endocytosis, ErbB3 is readily internalized even in the absence of added ligand and without requirement for kinase activity. Overexpression of ErbB2 has been demonstrated to inhibit epidermal growth f...
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