BACKGROUND The human lymphocyte antigen (HLA) molecule B*5101 is a functioning receptor of the immune system and is generally accepted as a genetic marker for Behçet disease (BD), a multi-organ, chronic inflammatory disorder. The role of the HLA-B*5101 in the pathogenesis of BD is elusive. The assumption that HLA-B*5101 has an active role in BD is suggestive, but no antigen has yet been identif...

OBJECTIVES To define the contribution of HLA genes and extended HLA haplotypes to the susceptibility to Behçet's disease (BD) in Sardinia. METHODS Forty-five unrelated Sardinian patients with BD, diagnosed according to the ISG criteria, 45 HLA-B*51 positive and 185 unselected healthy controls were enrolled in the study. DNA samples were typed for HLA class I and class II alleles and genotyped...

We report 18cm VLBI continuum imaging observations at ∼5 milliarcsecond resolution for UGC 5101, NGC 7469, and Mrk 231, all part of a sample of Luminous Infrared Galaxies which have been shown to have strong VLBI radio cores in a previous 18cm VLBI survey. Mrk 231, generally considered to be a dust-enshrouded QSO, shares many characteristics with quasars, including a broad, Sy1 optical emission...

KIR3DL1 is a polymorphic, inhibitory NK cell receptor specific for the Bw4 epitope carried by subsets of HLA-A and HLA-B allotypes. The Bw4 epitope of HLA-B*5101 and HLA-B*1513 is determined by the NIALR sequence motif at positions 77, 80, 81, 82, and 83 in the alpha(1) helix. Mutation of these positions to the residues present in the alternative and nonfunctional Bw6 motif showed that the func...

The crystal structures of the human MHC class I allele HLA-B*5101 in complex with 8-mer, TAFTIPSI, and 9-mer, LPPVVAKEI, immunodominant peptide epitopes from HIV-1 have been determined by x-ray crystallography. In both complexes, the hydrogen-bonding network in the N-terminal anchor (P1) pocket is rearranged as a result of the replacement of the standard tyrosine with histidine at position 171....

A dual specific human CTL clone harboring one beta and two inframe alpha transcripts of TCR was previously reported to recognize an HIV Pol-derived nonapeptide (IPLTEEAEL) endogenously presented by both syngeneic HLA-B*3501 and HLA-B*5101. In the current study, a retrovirus-mediated TCR transfer of individual alpha- and beta-chains to TCR-negative hybridoma showed that Valpha12.1 TCR in complex...

Summary Occupational dermatoses are among the most common occupational diseases, with BK 5101 accounting for largest proportion. Historically, latter was also frequently reported group of diseases within working age population. More than 80,000 suspected cases were notified in 2019, which 19,883 related to 5101. In Germany, work‐related hand eczema accounts 90 % all and consists mainly contact ...

Zusammenfassung Berufsdermatosen gehören zu den häufigsten Berufskrankheiten (BK), wobei die BK 5101 größten Anteil ausmacht und in der Vergangenheit am gemeldete Berufskrankheit bei Erwerbstätigen war. Im Jahr 2019 wurden mehr als 80 000 Verdachtsmeldungen auf gestellt, von denen 19 883 entfielen. Das berufsbedingte Handekzem, welches sich vor allem Kontaktekzem präsentiert, macht 90 % aller 5...

Department of Pharmacy, Kochi Medical School Hospital, 185-1 Kohasu, Oko, Nankoku, Kochi 783-8505, Japan Department of Biomedical Science, Kochi Medical Graduate School, 185-1 Kohasu, Oko, Nankoku, Kochi 783-8505, Japan Kochi Prefectural Industrial Technology Center, 3992-3 Nunoshida, Kochi, Kochi 781-5101, Japan Faculty of Agriculture, Kochi University, 200 Monobe, Nankoku, Kochi 783-8502, Jap...

Soma General Hospital, 142 Tsubogasaku, Niinuma, Soma, Fukushima 976-0011, Japan Research Group for Radiation and Biomolecular Science, Quantum Beam Science Center, Japan Atomic Energy Agency, 2-4 Shirakata-Shirane, Tokai, Ibaraki 319-1195, Japan *Corresponding Author: Soma General Hospital, 142 Tsubogasaku, Niinuma, Soma, Fukushima 976-0011, Japan. Tel: +81-244-36-5101; Fax: +81-244-35-5819; E...