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In the present chapter we discuss methodologies for the modelling, calibration and validation of cellular signalling pathway dynamics. The discussion begins with the typical range of techniques for modelling that might be employed to go from the chemical kinetics to a mathematical model of biochemical pathways. In particular, we consider the decision making processes involved in selecting the r...

Left ventricular (LV) midwall shortening (MWS) is subnormal in relation to LV circumferential end-systolic stress (ESS) (ESS-corrected MWS) in many hypertensive patients with normal LV chamber function and predicts subsequent morbidity and mortality. However, little is known of the relations of LV midwall function to demographic and metabolic variables or to arterial geometry. Asymptomatic, unm...

Предлагаются методологические основы проектирования инструментального комплекса онтологического назначения, предназначенного для реализации интегрированной информационной технологии автоматизированного построения онтологий предметных областей. Полученные результаты ориентированы на повышение эффективности анализа и понимания естественноязыковых текстов, построения баз знаний предметных областей...

On electropolished steel at low current densities, morphology and texture of electrodeposited zinc were investigated. Zinc coating is consisted of hexagonal crystallites laid on each other to produce packets. These packets are of different sizes and are stacked in different orientations to construct a homogeneous coating on steel substrate. This coating does not have texture, i.e., it has a ran...