Предлагаются методологические основы проектирования инструментального комплекса онтологического назначения, предназначенного для реализации интегрированной информационной технологии автоматизированного построения онтологий предметных областей. Полученные результаты ориентированы на повышение эффективности анализа и понимания естественноязыковых текстов, построения баз знаний предметных областей...

KIR3DL1 is an inhibitory HLA-B receptor of human NK and T cells that exhibits genetic and phenotypic polymorphism. KIR3DL1*004, a common allotype, cannot be detected on the surface of PBLs using the KIR3DL1-specific Ab DX9. The nature of this phenotype was investigated through comparison of 3DL1*004 with 3DL1*002, an allele giving high DX9 binding to cell surfaces. Analysis of Jurkat T cell tra...

1.  MXN-004 is a water-soluble PEGylated 7-ethyl-10-hydroxy-camptothecin (SN38). The aim of this study was to evaluate the in vitro cytotoxicity of MXN-004 and investigate pharmacokinetics and tissue distribution of MXN-004 and its active metabolite SN38 in rats. 2.  In vitro cytotoxicity of MXN-004 was tested in A549, HepG2 and Caco-2 cancer cell lines by a 3-(4,5-dimethylthiazol-2-yl)-2,5-dip...

S.N.Sivanandam P.Visalakshi [email protected] [email protected] A.Bhuvaneswari [email protected] 1 Professor and Head, Department of Computer Science and Engineering, PSG College of Technology, Coimbatore, Tamilnadu, India – 641 004. 2 Senior Lecturer, Department of Computer Science and Engineering, PSG College of Technology, Coimbatore, Tamilnadu, India – 641 004. 3 PG Student, ...

BACKGROUND AND OBJECTIVES MUC1 is over-expressed and aberrantly glycosylated in >60% of human pancreatic cancer (PC). Development of novel approaches for detection and/or targeting of MUC1 are critically needed and should be able to detect MUC1 on PC cells (including cancer stem cells) and in serum. METHODS The sensitivity and specificity of the anti-MUC1 antibody, TAB 004, was determined. CS...

Background. ß-lactam antibiotics that are excreted into the intestine can damage the microflora, which can lead to serious infections such as Clostridium difficile (C. diff ). SYN-004 is a potent ß-lactamase formulated for oral use with intravenous (IV) antibiotics to degrade antibiotics in the intestine. Methods. SYN-004, formerly called P3A, was developed and evaluated by Ipsat Therapies, Hel...