We study the interaction of suitable small and high frequency waves evolving by the flow of the Benjamin-Ono equation. As a consequence, we prove that the flow map of the Benjamin-Ono equation can not be uniformly continuous on bounded sets of H s (R) for s > 0.

In this paper, results of an empirical comparison of objects-first vs. objects-later are presented and discussed. The study was carefully designed to align the two approaches so that the comparison is focused on the main difference between the two approaches; that is the different sequence in which topics are taught: object oriented topics from the beginning or not. The study with duration of o...

So what is the Tadpole Topaz and what does it have to offer? That would be a tough, rugged notebook computer with a large 15.1-inch 1400 x 1050 pixel sunlight-viewable display and enough performance to power through very demanding applications, delivering stunning graphics performance in the process. While the Topaz is compact and lightweight by military standards, that still means a 12-pound p...

Don’t you just hate it when some marketing guy labels something as “ultimate”? Well, I’ve found something that really should be labeled as “ultimate”. It’s General Dynamics (GD) Itronix’ brand-new DynaVue outdoor-readable touch-screen display technology. The American Heritage Dictionary defines “ultimate” as “representing or exhibiting the greatest possible development or sophistication”, and t...

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Cyto-012 is a recombinant derivative of Botulinum neurotoxin Type A (BoNT/A). It primarily differs from wild type (wt) BoNT/A1 in that it incorporates two amino acid substitutions in the catalytic domain of the light chain (LC) metalloprotease (E224 > A and Y366 > A), designed to provide a safer clinical profile. Cyto-012 is specifically internalized into rat cortical and hippocampal neurons, a...

OBJECTIVES AMP activated protein kinase (AMPK) regulates the coordination of anabolic and catabolic processes and is an attractive therapeutic target for T2DM, obesity and metabolic syndrome. We report the anti-hyperglycemic and anti-hyperlipidemic effects of CNX-012-570 is an orally bioavailable small molecule (molecular weight of 530 Daltons) that directly activates AMPK in DIO and db/db anim...