Cantharidin isolated from Mylabris caraganae and other insects has been used as an anti-cancer drug in China for many years. However, its toxicity on the renal system and suppression effect on bone marrow limits its usage clinically. A synthetic analogue of cantharidin (CAN 037) has been shown to have cytotoxic effect on the SK-Hep 1 hepatoma cell line but its underlying working principle remai...

A single 1-g or 2-g intravenous dose of the cephalosporin FK-037 was given over 30 min in a cross-over-designed study, to each of six healthy male volunteers, and the concentrations of the drug were measured in plasma and cantharides-induced blister fluid over the subsequent 12 h. Urine was collected over 24 h. After a washout period of 6 weeks, during which the blisters healed, the study was r...

CME Outfi tters designates this enduring material for a maximum of 1 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. STATEMENT OF NEED Insomnia can affect many aspects of an individual’s life— impairing concentration and memory, increasing the risk of incident depression or recurrence of a depressive episo...

FK-037, a new parenteral cephalosporin, was tested against 483 organisms from clinical infections to establish preliminary susceptibility testing criteria with 30-micrograms disks. The proposed breakpoint zone diameters were > or = 17 mm (MIC correlate, < or = 8 micrograms/ml) for the susceptible category and < or = 13 mm (MIC correlate, > or = 32 micrograms/ml) for the resistant category. Thes...

Aims. The goal of this study is to analyze the H i supershell GS 121–05–037 and its role in triggering star formation. Methods. To characterize supershell, we analyzed 21-cm line far-infrared emission distributions. In addition, formation processes related 121-05-037, used Gaia survey, together with spectrophotometric calculations, derived a method look for massive OB–type stars. Results. chara...

In a multicenter study, the MICs of FK-037 for 90% of the strains tested (MIC90s) were < or = 1 microgram/ml for members of the family Enterobacteriaceae other than Citrobacter freundii, Enterobacter spp., and Serratia marcescens. Activity against Pseudomonas aeruginosa was variable, with a MIC50 and a MIC90 of 4 and 32 micrograms/ml, respectively. Relative to cefepime, however, FK-037 was less...

We present a first study of the channel H,A → ττ → h + h + X in CMS at high mA values where no triggering difficulties are expected with QCD jets. At present the τ selection is based solely on the presence of a hard isolated track in the ”τ” jet, but further refinements based on calorimeter collimation or impact parameter selections are obviously possible. The main irreducible background in the...