1Member of JSCE, Associate Professor, Crisis & Security Management Research Center, Kagawa University (2217-20 Hayashi-cyo, Takamatsu, 761-0396, Japan) E-mail: [email protected] 2Member of JSCE, Graduate School of Kagawa University (2217-20 Hayashi-cyo, Takamatsu, 761-0396, Japan) E-mail: [email protected] 3Member of JSCE, Professor, Crisis & Security Management Researc...

code: 002-0547

Mibefradil is a Ca2+ channel antagonist that inhibits both T-type and high-voltage-activated Ca2+ channels. We previously showed that block of high-voltage-activated channels by mibefradil occurs through the production of an active metabolite by intracellular hydrolysis. In the present study, we modified the structure of mibefradil to develop a nonhydrolyzable analog, (1S, 2S)-2-(2-(N-[(3-benzi...

[This corrects the article DOI: 10.1160/TH14-06-0547.].

A novel mibefradil derivative, NNC55-0396, designed to be hydrolysis-resistant, was shown to be a selective T-type Ca(2+) channel inhibitor without L-type Ca(2+) channel efficacy. However, its effects on cytochromes P450 (P450s) have not previously been examined. We investigated the inhibitory effects of NNC55-0396 toward seven major recombinant human P450s--CYP3A4, CYP2D6, CYP1A2, CYP2C9, CYP2...

Accumulating evidence reports that T-type calcium channels play crucial roles in tumor formation and development. However, the of inhibiting cells with various inhibitors progression remain unclear. This study aimed to investigate cytotoxic apoptotic effects NNC 55-0396, a channel inhibitor, against SNU-1 gastric cancer cells. Cytotoxic 55-0396 were evaluated by XTT assay flow cytometry. The re...

198 words; Text4628 words Blood First Edition Paper, prepublished online June 24, 2004; DOI 10.1182/blood-2004-02-0547 Copyright (c) 2004 American Society of Hematology only. For personal use at PENN STATE UNIVERSITY on February 23, 2013. bloodjournal.hematologylibrary.org From

Abstract Introduction RLS affects 5%-10% of European and North American adults, with 2%-3% experiencing moderate to severe symptoms. patients, often undiagnosed or improperly treated, experience significant depression in addition loss sleep. Methods ODYSSEY II, an online in-print self-administered questionnaire (respondents primarily from the United States) included validated questions on diagn...

BACKGROUND T-type Ca(2+) channels are often aberrantly expressed in different human cancers and participate in the regulation of cell cycle progression, proliferation and death. METHODS RT-PCR, Q-PCR, western blotting and whole-cell patch-clamp recording were employed to assess the expression of T-type Ca(2+) channels in leukemia cell lines. The function of T-type Ca(2+) channels in leukemia ...

There is concern regarding neurotoxicity induced by the use of local anesthetics. A previous study showed that an overload of intracellular calcium is involved in the neurotoxic effect of some anesthetics. T-type calcium channels, which lower the threshold of action potentials, can regulate the influx of calcium ions. We hypothesized that T-type calcium channels are involved in bupivacaine-indu...