It is important to prevent nausea and vomiting to maintain both the quality of life of patients with cancer and the efficacy of chemotherapy. The aim of this study was to examine the efficacy of aprepitant for treatment of chemotherapy-induced nausea and vomiting (CINV) in Japanese patients with gastrointestinal cancer receiving highly or moderately emetogenic chemotherapy (HEC or MEC) regimens...

Epilepsy, a common neurological disorder, is characterized by the occurrence of spontaneous recurrent epileptiform discharges (SREDs). Acquired epilepsy is associated with long-term neuronal plasticity changes in the hippocampus resulting in the expression of spontaneous recurrent seizures. The purpose of this study is to evaluate and characterize endogenous epileptiform activity in hippocampal...

OBJECTIVE To evaluate the efficiency of resources allocation and sustainability of the use of netupitant+palonosetron (NEPA) for chemotherapy-induced nausea and vomiting (CINV) prophylaxis assuming the Italian National Health Service (NHS) perspective. A published Markov model was adapted to assess the incremental cost-utility ratio of NEPA compared with aprepitant (APR) + palonosetron (PALO), ...

To deliver and retain viable repair cells in a surgically prepared cartilage lesion, we previously developed an adhesive in situ-gelling cell carrier by suspending cells in a solution of hydroxyethyl cellulose (HEC), which was then mixed with chitosan-glycerol phosphate to form a chitosan-GP/HEC gel. The purpose of this study was to elucidate the mechanism of gelation to maximally control gel t...

A systematic study of the effects of polymer surface properties on the interaction with human endothelial cells (HEC) may lead to the development of small-diameter vascular grafts. HEC, suspended in culture medium containing 20% serum adhered and spread onto moderately wettable polymers such as TCPS (tissue culture polystyrene). Reduced or no adhesion of HEC was observed upon the hydrophobic po...

This paper presents a modeling application of surface runoff using the Hydrologic Modelling System (HEC-HMS). A case study was carried out for the Jianghe watershed, a typical semi-arid and sub-humid geo-climatic region in northern China. Two modeling schemes using different descriptive sub-mechanism models provided by HEC-HMS for runoff volume, direct runoff and routing (channel flow) were inv...

OBJECTIVE Preferential IGF-1Ec expression has been firmly associated with skeletal muscle repair mechanisms, post-infarction remodeling of the myocardium, the pathophysiology of endometriosis and prostate cancer biology. Therefore, we have studied the possible biological significance of synthetic Ec peptide, a putative cleavage product of IGF-1Ec in PC-3 cells and C2C12 myoblasts. DESIGN We h...

Scientific high-end computing (HEC) has become an important tool for scientists world-wide to understand problems, such as in nuclear fusion, human genomics and nanotechnology. Every year, new HEC systems emerge on the market with better performance and higher scale. With only very few exceptions, the overall availability of recently installed systems has been lower in comparison to the same de...

The role, effectiveness, and even existence of hospital ethics committees (HECs) are not universally agreed upon. Over the past 20 years, the study of HECs has focused mainly on their structure, scope, and function, making the results more descriptive than anything. In an effort to present study results that could help HECs better serve the needs of their organizations, the authors of this arti...