نتایج جستجو برای: 1 – حساس کنندگی پرتوی 2 – گلیوما 3 – اسفرویید 4 – iudr 5 – comet
تعداد نتایج: 5183178 فیلتر نتایج به سال:
زمینه و هدف: آزمایشات مختلف in vitro و in vivo نشان داده اند که استفاده از حساس کننده های پرتوی در پرتودرمانی، ابزار مفیدی در درمان سرطان گلیوما است. بسیاری از دودمان های سلولی تحت شرایط خاص تجمع یافته و با رشد، ساختارهای چندسلولی به نام اسفرویید(spheroid) تشکیل می دهند. این اسفروییدها از ابعاد مختلف، شبیه تومورهای in vivo می باشند. بنابراین مطالعه خصوصیات رشد و رفتار اسفروییدها، نقش مهمی در در...
زمینه و هدف: 5-ایدو2-دئوکسی یوریدین(iudr)، آنالوگ تیمیدین و به عنوان حساس کننده پرتوی سلول های سرطان انسانی در in vitro و in vivo شناخته شده است. مطالعات بر روی اسفروییدها نشان داده است که افزایش زمان انکوباسیون iudr سبب افزایش برداشت سلول ها می شود. هدف از این مطالعه، بررسی میزان صدمات سیتوژنتیکی ناشی از پرتوهای یونیزان طی زمان های مختلف انکوباسیون سلول ها با iudr در مدل کشت اسفرویید و تعیین ز...
Background & Aim: In vitro experiments and in vivo studies have revealed that radiosensitizers in radiation therapy may serve as powerful tools in the treatment of glioma cancers. Many cell lines, under some specific conditions will aggregate and grow to form multicellular structures called spheroid. Thses spheroids resemble in vivo tumor models in several aspects. Therefore studying growth...
objective: in this study, we investigated the combined effect of 2-methoxyestradiol (2me2) and 60co on the cytogenetic damage of iododeoxyuridine (iudr) in the spheroid model of u87mg glioblastoma cancer cell lines by alkaline comet assay. materials and methods: u87mg cells were cultured as spheroids with diameters of 350 μm. as control, the spheroids of one plate were not treated. other cultur...
The purpose of this study was to evaluate the effect of resveratrol on cytogenetic damages of iododeoxyuridine (IUdR) and x-ray megavoltage radiation (6 MV) in spheroid model of U87MG glioblastoma cancer cell line using clonogenic and alkaline comet assay. Cells were cultured as spheroids (350 µm) that were treated with 20 μM resveratrol, 1 μM IUdR and 2 Gy of 6 MV x-ray. After treatment, viabi...
OBJECTIVE In this study, we investigated the combined effect of 2-Methoxyestradiol (2ME2) and (60)Co on the cytogenetic damage of iododeoxyuridine (IUdR) in the spheroid model of U87MG glioblastoma cancer cell lines by alkaline comet assay. MATERIALS AND METHODS U87MG cells were cultured as spheroids with diameters of 350 µm. As control, the spheroids of one plate were not treated. Other cult...
OBJECTIVE In radiation treatment, the irradiation which is effective enough to control the tumors far exceeds normal-tissues tolerance. Thus to avoid such unfavourable outcomes, some methods sensitizing the tumor cells to radiation are used. Iododeoxyuridine (IUdR) is a halogenated thymidine analogue that known to be effective as a radiosensitizer in human cancer therapy. Improving the potentia...
Background & Aim: 5-iodo-2-deoxyuridine(Iudr) is a thymidine analog that is known as a radiosensitizer for human cancer cells in in vitro and in vivo studies. The investigations on the spheroid have shown that Iudr uptake of cells increases with the increasing Iudr incubation time. The aim of this study was to evaluate the extent of cytogenetic damage induced by ionizing radiation at differ...
objective: in radiation treatment, the irradiation which is effective enough to control the tumors far exceeds normal-tissues tolerance. thus to avoid such unfavourable outcomes, some methods sensitizing the tumor cells to radiation are used. iododeoxyuridine (iudr) is a halogenated thymidine analogue that known to be effective as a radiosensitizer in human cancer therapy. improving the potenti...
PURPOSE 5-iodo-2-pyrimidinone-2'-deoxyribose (IPdR) is a pyrimidinone nucleoside prodrug of 5-iododeoxyuridine (IUdR) under investigation as an orally administered radiosensitizer. We previously reported that the mismatch repair (MMR) proteins (both hMSH2 and hMLH1) impact on the extent (percentage) of IUdR-DNA incorporation and subsequent in vitro IUdR-mediated radiosensitization in human tumo...
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