نتایج جستجو برای: 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)

تعداد نتایج: 930163  

Journal: :Chemical communications 2016
Antonio Bermejo Gómez Miguel A Cortés González Marvin Lübcke Magnus J Johansson Christer Halldin Kálmán J Szabó Magnus Schou

Nucleophilic 18F-fluorination of bromodifluoromethyl derivatives was performed using [18F]Bu4NF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [18F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.

2016
Madhuri Vangala Ganesh P Shinde

The amidine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) and DBN (1,5-diazabicyclo[4.3.0]non-5-ene) display nucleophilic behaviour towards highly electrophilic p-nitrophenyl carbonate derivatives with ring opening of the bicyclic ring to form corresponding substituted ε-caprolactam and γ-lactam derived carbamates. This simple method presents a unified strategy to synthesize structurally diver...

A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against t...

Journal: :Molecules 2015
Brigita Vigante Martins Rucins Aiva Plotniece Karlis Pajuste Iveta Luntena Brigita Cekavicus Egils Bisenieks Rufus Smits Gunars Duburs Arkadij Sobolev

The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions. The use of TBD is crucial for the successful aminolysis of ethoxycarbonylmethyl ester of 1,4-dihydropyridines with secondary amines as without it the reaction does not proceed a...

Journal: :Chemical communications 2015
Norio Sakai Minoru Sasaki Yohei Ogiwara

The combination of a catalytic amount of Cu(OTf)2 and less than a stoichiometric amount of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under an O2 atmosphere effectively promoted the N-nitrosation of both secondary aromatic/aliphatic amines and tertiary aromatic amines with nitromethane (CH3NO2) leading to the preparation of N-nitrosamine derivatives.

Journal: :Chemical communications 2013
Abdul Karim Haji Dheere Nadiya Yusuf Antony Gee

A rapid urea radiolabelling methodology has been developed. [(11)C]CO2 was activated by 1,8-diazabicycloundec-7-ene (DBU) in the presence of aliphatic and aromatic amines and reacted with Mitsunobu reagents to produce asymmetric (11)C radiolabelled ureas in high radiochemical yields.

Journal: :iranian journal of pharmaceutical research 0
afsaneh zonouzi school of chemistry, university college of science, university of tehran, p.o. box 14155-6455, tehran, iran roghieh mirzazadeh school of chemistry, university college of science, university of tehran, p.o. box 14155-6455, tehran, iran maliheh safavi institute of biochemistry and biophysics, department of biochemistry, university of tehran, tehran, iran sussan k ardestani institute of biochemistry and biophysics, department of biochemistry, university of tehran, tehran, iran saeed emami department of medicinal chemistry and pharmaceutical sciences research center, faculty of pharmacy, mazandaran university of medical sciences, sari, iran. alireza foroumadi 1- faculty of pharmacy and pharmaceutical sciences research center, tehran university of medical sciences, tehran, iran. 2- drug design and development research center, tehran university of medical sciences, tehran, iran.

a series of 2-amino-4-(nitroalkyl)-4h-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using dbu (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. the cytotoxic activity of target compounds were evaluated against t...

Journal: :European Journal of Organic Chemistry 2022

We report the direct incorporation of hexafluoroisobutyl group on a chiral glycine Schiff base complex mediated by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). The fluoroalkylation involves 2-(bromomethyl)-1,1,1,3,3,3-hexafluoropropane reagent, which generates in situ hexafluoroisobutylene (HFIB), and reacts then with enolate through tandem allylic shift/hydrofluorination process. showed that use ...

A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against t...

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