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In vivo, beta(2) integrins and particularly alpha(L)beta(2) (LFA-1) robustly support firm adhesion of leukocytes, but can also cooperate with other molecules in supporting rolling adhesion. Strikingly, a small molecule alpha/beta I-like allosteric antagonist, XVA143, inhibits LFA-1-dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and i...
http://www.aic.gov.au Corruption, defined here as the exploitation of public office for personal gain, is a universal phenomenon. The practice, in one manifestation or another, is as old as government itself. Today, it thrives in the world’s wealthiest nations, and in its poorest. It exists on every continent, across people of all nationalities and religions. Corruption can take many forms, inc...
The Rockefeller University Press $30.00 J. Cell Biol. Vol. 209 No. 1 143–162 www.jcb.org/cgi/doi/10.1083/jcb.201407130 JCB 143 Correspondence to Chang-Duk Jun: [email protected] Abbreviations used in this paper: ABM, actin-binding motif; APB, actin polymerization buffer; APC, antigen-presenting cell; Arp2/3, Actin-related protein 2/3; CFSE, carboxyfluorescein succinimidyl ester; CH, calponin hom...
Mosquitoes transmit serious human diseases, causing millions of deaths every year. Use of synthetic insecticides to control vector mosquitoes has caused physiological resistance and adverse environmental effects in addition to high operational cost. Insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. The present investigations were made to eva...
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