نتایج جستجو برای: 1] Tetrazolo [4

تعداد نتایج: 3363214  

2013
Lyudmyla M. Antypenko Sergey I. Kovalenko Olexii M. Antypenko Andrey M. Katsev Olena M. Achkasova

The novel heterocyclization of 5-(2-aminophenyl)-1H-tetrazole with potassium ethylxanthogenate or carbon disulfide was proposed. The potassium salt of the tetrazolo[1,5-c]quinazoline-5-thione was subsequently modified by alkylation with proper halogen derivatives to (tetrazolo[1,5-c]quinazolin-5-ylthio)alkyls, N,N-dialkylethylamines, 1-aryl-2-ethanones, 1-(alkyl)aryl-2-ethanols, carboxylic acid...

Journal: :Scientia pharmaceutica 2016
Oleksii M Antypenko Sergiy I Kovalenko Galina O Zhernova

Methods of 1-[2-(1H-tetrazol-5-yl)-R(1)-phenyl]-3-R(2)-phenyl(ethyl)ureas and R(1)-tetrazolo[1,5-c]quinazolin-5(6H)-ones synthesis were designed. IR, LC-MS, (1)H NMR, and elemental analysis data evaluated the structure and purity of the obtained compounds. Different products, depending on the reaction conditions, were distinguished and discussed. The preliminary hypoglycemic activity of 36 synt...

2013
Gautam Chattopadhyay Partha Sinha Ray

1-Benzyl-5-aminoimidazole-4-carboxamide 1a has been used as a convenient precursor for the synthesis of new triazolo [3,4-i] purines 6 and the corresponding tetrazolo analogue 7. A mesoionic isomer 8 seems to exist along with 7. Interesting heteroaryl-purine motifs have also been prepared via suitably substituted 9-benzylpurines. Imidazo [1,5-a] pyrazine derivative has been prepared in a solid ...

Journal: :Molecules 2015
Aisha R Al-Marhabi Hebat-Allah S Abbas Yousry A Ammar

In continuation of our endeavor towards the development of potent and effective anticancer and antimicrobial agents; the present work deals with the synthesis of some novel tetrazolo[1,5-a]quinoxalines, N-pyrazoloquinoxalines, the corresponding Schiff bases, 1,2,4-triazinoquinoxalines and 1,2,4-triazoloquinoxalines. These compounds were synthesized via the reaction of the key intermediate hydra...

Journal: :Acta Crystallographica Section E Structure Reports Online 2010

2017
Elisandra Scapin Paulo R S Salbego Caroline R Bender Alexandre R Meyer Anderson B Pagliari Tainára Orlando Geórgia C Zimmer Clarissa P Frizzo Helio G Bonacorso Nilo Zanatta Marcos A P Martins

An efficient synthesis methodology for a series of tetrazolo[1,5-a]pyrimidines substituted at the 5- and 7-positions from the cyclocondensation reaction [CCC + NCN] was developed. The NCN corresponds to 5-aminotetrazole and CCC to β-enaminone. Two distinct products were observed in accordance with the β-enaminone substituent. When observed in solution, the compounds can be divided into two grou...

Journal: :MedChemComm 2014
André Boltjes George P Liao Ting Zhao Eberhardt Herdtweck Alexander Dömling

A three step synthesis of N-unsubstituted tetrazolo γ- and δ-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the N-unsubstituted γ- and δ-lactam fragment reveals a strongly tri-directional hydrogen bond donor acceptor interaction with the amino acids of the binding sites.

Journal: :Acta Crystallographica Section E Structure Reports Online 2010

Journal: :Molecules 2017
Malose J Mphahlele Samantha Gildenhuys Nishal Parbhoo

In this paper, we describe the synthesis of the 5-styryltetrazolo[1,5-c]quinazolines substituted at the 9-position with a 4-fluorophenyl ring directly or via a conjugated π-spacer (C=C or C≡C bond) based on the 6-bromo-4-chloro-2-styrylquinazoline scaffold. The structures of the synthesized compounds were characterized based on a combination of ¹H-NMR, 13C-NMR, IR and high resolution mass spect...

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